The Baseline Nutritional Status Predicts Long-Term Mortality in Patients Undergoing Endovascular Therapy

Nutrients
Keiko MizobuchiNobuhisa Hagiwara

Abstract

Peripheral artery disease (PAD) occurs at an advanced stage of atherosclerosis and its comorbidities are associated with poor prognoses. Malnutrition is related to the severity of atherosclerosis in patients with cardiovascular disease and it predicts mortality. The Controlling Nutritional Status (CONUT) score is calculated from serum albumin concentration, peripheral lymphocyte count and total cholesterol concentration, and it robustly represents the nutritional status of hospitalized patients. This study aimed to determine the prognostic value of the CONUT score in patients with peripheral artery disease (PAD) who were undergoing endovascular therapy (EVT). This study included 628 PAD patients who underwent EVT between 2013 and 2017 and were assigned to low (CONUT score 0: n = 81), mild (CONUT score 1-2: n = 250), moderate (CONUT score 3-4: n = 169), and high (CONUT score ≥ 5: n = 128) risk groups. The study's primary endpoint was any death. Patients in the groups with higher CONUT scores were more likely to have chronic kidney disease (p < 0.001), impaired left ventricular ejection fractions (p < 0.001), and critical limb ischemia (p < 0.001) on admission. During follow-up, 95 patients (15%) died. Kaplan-Meier analyses revea...Continue Reading

References

Jan 14, 1999·The New England Journal of Medicine·R Ross
Sep 3, 2003·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·U Julius
Dec 20, 2003·American Journal of Surgery·Robert G Frykberg
May 17, 2005·Journal of the American College of Cardiology·Benjamin D HorneUNKNOWN Intermountain Heart Collaborative Study Group
Feb 2, 2006·JAMA : the Journal of the American Medical Association·Graeme J HankeyJohn W Eikelboom
Aug 16, 2006·Circulation·Beatrice A GolombMichael H Criqui
Jan 18, 2007·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Y JaccardI Baumgartner
Jun 25, 2010·Journal of Vascular Surgery·James Ian SparkSonal Asthana
Aug 28, 2012·Nature Reviews. Cardiology·Diana P BrostowMindy S Kurzer
May 22, 2013·Journal of Vascular Surgery·Christian HøyerLars J Petersen
Jul 3, 2013·Circulation Journal : Official Journal of the Japanese Circulation Society·Kotaro NochiokaUNKNOWN CHART-2 Investigators
Jan 31, 2014·Current Heart Failure Reports·Luis SargentoRoberto Palma dos Reis
Jul 30, 2015·European Journal of Heart Failure·Hiroaki ShimokawaYasuhiko Sakata
Aug 28, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Nozima BuronovaNobuhisa Hagiwara
Jan 20, 2016·Journal of Atherosclerosis and Thrombosis·Akihiro NakagomiWataru Shimizu
Mar 18, 2016·Vascular and Endovascular Surgery·Lorena GonzalezVivian Gahtan
Nov 20, 2016·International Journal of Cardiology·Jacob TepermanBinita Shah
Jan 1, 2017·International Journal of Cardiology·Daisuke SuetaUNKNOWN Multi-center Study of Hemodialysis Patients Undergoing Invasive Cardiovascular Procedures Study Investigators
Sep 3, 2017·The Lancet. Diabetes & Endocrinology·Andrew MenteUNKNOWN Prospective Urban Rural Epidemiology (PURE) study investigators
Sep 20, 2017·Lipids in Health and Disease·Cintia Botelho DiasManohar L Garg
Sep 22, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Iwao OkaiHiroyuki Daida
May 31, 2018·Atherosclerosis·Jun Shu, Gaetano Santulli
Jul 15, 2018·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Dorothee VolkertStephan C Bischoff

❮ Previous
Next ❯

Citations

Jun 27, 2020·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Masahiko FujiharaMitsuyoshi Takahara
Nov 26, 2020·The American Journal of Clinical Nutrition·Shirley SzeAndrew L Clark
Feb 17, 2021·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Shunsuke HinoNorio Horie

❮ Previous
Next ❯

Methods Mentioned

BETA
amputations
amputation

Software Mentioned

R Foundation for Statistical Computing
R

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.