The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer

Oncology
Takeharu YamanakaMasanori Fukushima

Abstract

In cancer patients, the balance between neutrophil (N) and lymphocyte (L) cell counts fluctuates with advancing disease. The objective of our study was to determine the prognostic implications of the N/L ratio in the peripheral blood of gastric cancer patients. Study participants were identified from a prospective cohort of patients with advanced gastric cancer in Japan (n = 1,220). The median baseline N/L was 2.58 (range, 0.63-12.7). Univariate analysis revealed that patients with an N/L > pr =2.5 (n = 644) had a significantly poorer prognosis than those with an N/L <2.5 (n = 576; log rank test, p = 0.019 x 10(-12)). The median survival times for these two groups were 239 (95% confidence interval, CI, 217-251 days) and 363 days (95% CI, 334-406 days), respectively, while the 1-year survival rates were 30 (95% CI, 26-34%) and 50% (95% CI, 45-54%), respectively. A multivariate Cox model established a significant relationship between the N/L ratio and survival (adjusted hazard ratio = 1.52; 95% CI, 1.32-1.75; p = 0.077 x 10(-8)). These results suggest that the N/L ratio is an independent prognostic factor in advanced gastric cancer. Measurement of this ratio may serve as a clinically accessible and useful biomarker for patient su...Continue Reading

Associated Clinical Trials

Dec 4, 2019·mehmet ozsurmeli

Citations

Sep 8, 2010·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hideaki ShimadaMatsuo Nagata
Nov 22, 2011·Annals of Biomedical Engineering·Yue GengMichael R King
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·S CedrésE Felip
Nov 6, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xin AnYu-Hong Li
Mar 26, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Donald C McMillan
Jun 21, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Devin C KoestlerKarl T Kelsey
Aug 28, 2012·Dementia and Geriatric Cognitive Disorders·Mehmet Emin KuyumcuServet Arıoğul
Jul 19, 2013·The Journal of Clinical Investigation·Jonathan Cools-LartigueLorenzo Ferri
Oct 12, 2012·Annals of Surgical Oncology·Daniel R PerezRonald P Dematteo
Dec 19, 2009·PloS One·Andrew E TeschendorffMartin Widschwendter
May 31, 2014·Journal of the National Cancer Institute·Arnoud J TempletonEitan Amir
Jan 21, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·In Rae ChoYong Chan Lee
Dec 10, 2009·World Journal of Surgery·Yasuhiko MohriMasato Kusunoki
Jun 6, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Mehmet İlhanCemalettin Ertekin
Oct 24, 2013·Cutaneous and Ocular Toxicology·Bilge Bulbul SenNihat Sen
Feb 8, 2016·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Tadafumi AsaokaShoji Nakamori
Oct 11, 2011·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Won Ho KimMyung Hee Kim
Nov 21, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X XieJ Chen

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