The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in rectal carcinoma.

Journal of Gastrointestinal Cancer
Huanran LiuXiang Hu

Abstract

In cancer patients, the balance between neutrophil (N) and lymphocyte (L) cell counts fluctuates with advancing disease. The objective of our study was to determine the prognostic implications of the N/L ratio in the peripheral blood of rectal cancer patients. Study participants were identified from a prospective cohort of patients with rectal cancer in Dalian of China (n = 123). The median baseline N/L ratio was 2.41 +/- 2.206 (range, 0.76-20.45). Our results revealed that the N/L ratio was significantly associated with tumor size (P = 0.003) and level of cancer antigen 125 (P = 0.027). A multivariate Cox model established a significant relationship between the N/L ratio and survival (adjusted hazard ratio, 2.615; 95% confidence interval, 1.152-5.933; P = 0.021). These results suggest that the N/L ratio is an independent prognostic factor in rectal cancer, and the N/L ratio may serve as a clinically accessible and useful biomarker for patient survival.

References

Dec 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·H Böhrer, O Kick
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S AaltomaaK Syrjänen
Aug 6, 1998·Journal of Cancer Research and Clinical Oncology·M HirashimaH Okada
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrizia ScapiniMarco A Cassatella
Dec 10, 2002·International Journal of Cancer. Journal International Du Cancer·Helmut SchaiderMeenhard Herlyn
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Feb 6, 2003·British Journal of Cancer·J AtzpodienUNKNOWN DGCIN -- German Cooperative Renal Carcinoma Chemo-Immunotherapy Trials Group
Sep 2, 2003·Chemical Immunology and Allergy·E Di CarloP Musiani
Aug 25, 2005·Journal of Surgical Oncology·S R WalshN J Keeling
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frede Donskov, Hans von der Maase
Jun 11, 2009·Oncology Reports·Huanran LiuTakafumi Tabuchi

❮ Previous
Next ❯

Citations

Sep 14, 2010·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Douglas D BensonCarlton C Barnett
Jun 27, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·R CarruthersA C McDonald
May 31, 2014·Journal of the National Cancer Institute·Arnoud J TempletonEitan Amir
Jun 5, 2014·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Ronit Vogt SionovZvi Granot
Oct 15, 2013·International Journal of Cancer. Journal International Du Cancer·Mu-Xing LiYi Lv
Apr 25, 2015·Journal of Medical Imaging and Radiation Oncology·Carol R HaddadThomas Eade
Aug 22, 2015·BMC Cancer·Houda BahigDenis Soulieres
Jan 21, 2017·Journal of Surgical Oncology·Abdelhamed HaramMichael J Kerin
Mar 29, 2018·Journal of Gastrointestinal Cancer·Mohammad Abu-ShawerMaysa Al-Hussaini
Oct 30, 2016·The International Journal of Biological Markers·Zhu-Lin LiuZhen-Yu Ding
Sep 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Mehmet Naci AldemirSalim Basol Tekin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Yaojun ZhangMinshan Chen
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
C P NealD P Berry
Circulation Journal : Official Journal of the Japanese Circulation Society
Yasuko NishiokaOsamu Tochikubo
© 2021 Meta ULC. All rights reserved