PMID: 9419758Apr 1, 1994Paper

The basis and evidence of a role for the ovarian renin-angiotensin system in health and disease

Journal of the Society for Gynecologic Investigation
G NemethF Naftolin

Abstract

We reviewed the evidence for an intrinsic ovarian renin-angiotensin system (OVRAS), highlighting potential diverse signaling in this system through different bioactive angiotensin peptides, their specific receptors, and second messengers. In addition, sites of action for OVRAS in the regulation of ovarian function in health and disease were reviewed. We used published journals and abstracts from national scientific meetings. Current developments in the renin-angiotensin field are historically set. One hundred referenced articles provided studies on renin-angiotensin systems in mammalian species, including humans. Interpretation of the reviewed publication was in line with the original authors' conclusions and statistical analysis. Techniques in molecular biology, biochemistry, and immunohistochemistry have identified an OVRAS in mammalian species. Ovarian tissues contain all the elements for the production of angiotensin, including prorenin/renin, angiotensinogen, and angiotensin-converting enzyme. In addition, angiotensin II is present in ovarian compartments, and receptors for angiotensin II are demonstrated on specific ovarian cells. Angiotensin II is implicated to play a role in ovulation, steroidogenesis, follicular atresi...Continue Reading

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Citations

Jun 16, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G P VinsonO Djahanbakhch
Aug 19, 1999·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·J R Loret de MolaM A Friedlander
Nov 9, 2016·Reproductive Sciences·Angela PalumboFrederick Naftolin
May 20, 2000·Annals of the New York Academy of Sciences·E HassanS Michalas

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