The basolateral amygdala dopaminergic system contributes to the improving effect of nicotine on stress-induced memory impairment in rats

Progress in Neuro-psychopharmacology & Biological Psychiatry
Elnaz KeshavarzianAmeneh Rezayof

Abstract

Stress seems to be an important risk factor in the beginning and continuing stages of cigarette tobacco smoking in humans. Considering that both of nicotine administration and stress exposure affect cognitive functions including memory formation, the aim of the present study was 1) to evaluate the effect of subcutaneous (s.c.) administration of nicotine on memory formation under stress and 2) to assess the possible role of the basolateral amygdala (BLA) dopamine D1 and D2 receptors in the effect of nicotine on stress-induced memory retrieval impairment. Adult male wistar rats were bilaterally implanted in the BLA. A step-through type passive avoidance task was used to measure memory retrieval. To induce acute stress, the animals were placed on an elevated platform. The results showed that pre-test exposure to 20 and 30 min stress, but not 10 min, impaired memory retrieval. Nicotine administration (0.05 mg/kg, s.c.) improved stress-induced memory retrieval impairment. The activation of the BLA dopamine receptors via bilateral microinjection of apomorphine (0.025-0.4 μg/rat), a non-selective dopamine receptor agonist, potentiated the effect of nicotine on stress-induced memory retrieval impairment. Interestingly, intra-BLA microi...Continue Reading

References

Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·L XuM J Rowan
Feb 26, 1999·Journal of Neurochemistry·F M Inglis, B Moghaddam
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jong Y BahkMyeong O Kim
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Patrizia PorcuAlessandra Concas
Feb 1, 2003·Neurobiology of Learning and Memory·Benno Roozendaal
Jan 21, 2004·The Pharmacogenomics Journal·J ErblichD H Bovbjerg
Aug 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Siobhan RobinsonRichard D Palmiter
May 5, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jack H MendelsonNancy K Mello
Dec 1, 2005·The International Journal of Neuropsychopharmacology·Abdulaziz M AleisaKarim A Alkadhi
Jun 7, 2006·Stress : the International Journal on the Biology of Stress·Rose-Marie VouimbaDavid M Diamond
Dec 7, 2007·Neural Plasticity·Carmen Sandi, M Teresa Pinelo-Nava
May 16, 2008·Physiology & Behavior·Niloufar DarbandiMohammad-Reza Zarrindast
Oct 22, 2008·Physiology & Behavior·A M FalcoR F Smith
May 26, 2009·Behavioural Brain Research·Ameneh RezayofMohammad-Reza Zarrindast
Jun 12, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Amanda R de OliveiraMarcus L Brandão
Nov 28, 2013·The International Journal of Neuropsychopharmacology·Maryam SardariMohammad-Reza Zarrindast
Jul 17, 2014·Behavioural Pharmacology·Miao-Kun Sun, Daniel L Alkon
Aug 20, 2015·Learning & Memory·Eun Joo KimJeansok J Kim
Oct 27, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Damee ChoiShigeki Watanuki
Jan 13, 2017·Turkish Journal of Medical Sciences·Hoda RanjbarSara Karimi
Apr 4, 2017·Psychological Bulletin·Grant S ShieldsAndrew P Yonelinas
Apr 20, 2017·Pharmacological Reviews·Ryan T LaLumiereChrista K McIntyre

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Citations

Jun 10, 2020·Cold Spring Harbor Perspectives in Medicine·Miranda L FisherJill R Turner

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