The basolateral amygdala in reward learning and addiction

Neuroscience and Biobehavioral Reviews
Kate M Wassum, Alicia Izquierdo

Abstract

Sophisticated behavioral paradigms partnered with the emergence of increasingly selective techniques to target the basolateral amygdala (BLA) have resulted in an enhanced understanding of the role of this nucleus in learning and using reward information. Due to the wide variety of behavioral approaches many questions remain on the circumscribed role of BLA in appetitive behavior. In this review, we integrate conclusions of BLA function in reward-related behavior using traditional interference techniques (lesion, pharmacological inactivation) with those using newer methodological approaches in experimental animals that allow in vivo manipulation of cell type-specific populations and neural recordings. Secondly, from a review of appetitive behavioral tasks in rodents and monkeys and recent computational models of reward procurement, we derive evidence for BLA as a neural integrator of reward value, history, and cost parameters. Taken together, BLA codes specific and temporally dynamic outcome representations in a distributed network to orchestrate adaptive responses. We provide evidence that experiences with opiates and psychostimulants alter these outcome representations in BLA, resulting in long-term modified action.

References

Aug 1, 1972·Experimental Neurology·B Jones, M Mishkin
Feb 1, 1982·Journal of Comparative and Physiological Psychology·J P Aggleton, R E Passingham
Jul 1, 1993·The European Journal of Neuroscience·D GaffanM Fabre-Thorpe
Nov 1, 1995·Neurobiology of Learning and Memory·R P Kesner, J M Williams
Jun 27, 1998·Progress in Neurobiology·A J McDonald
Jan 29, 2000·The European Journal of Neuroscience·J A ParkinsonB J Everitt
Aug 31, 2001·Nature Neuroscience·D M HutchesonA Dickinson
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·Ronald E See
May 22, 2002·Neural Computation·Kenji DoyaMitsuo Kawato
May 30, 2002·Neuroscience and Biobehavioral Reviews·Rudolf N CardinalBarry J Everitt
Jul 3, 2002·Nature Reviews. Neuroscience·Mark G Baxter, Elisabeth A Murray
Sep 5, 2002·The Journal of Comparative Neurology·Lisa Stefanacci, David G Amaral
Aug 1, 1956·Journal of Comparative and Physiological Psychology·L WEISKRANTZ
Aug 1, 1960·Journal of Comparative and Physiological Psychology·J S SCHWARTZBAUM
Nov 6, 2003·Neuroscience and Biobehavioral Reviews·Anthony G PhillipsJohn G Howland
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Catharine A WinstanleyTrevor W Robbins
Jun 24, 2004·Journal of Neurophysiology·Denis ParéJoseph E Ledoux
Jan 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Szu-Han WangBernard W Balleine
Jan 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laura H Corbit, Bernard W Balleine
May 6, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Laurie L WellmanLudise Malkova
Oct 28, 2005·Nature Neuroscience·Barry J Everitt, Trevor W Robbins
Nov 3, 2005·The European Journal of Neuroscience·Alicia Izquierdo, Elisabeth A Murray
Mar 21, 2006·Trends in Neurosciences·Bernard W Balleine, Simon Killcross
Aug 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dominic M Dwyer, Simon Killcross
Feb 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alicia Izquierdo, Elisabeth A Murray
Mar 9, 2007·Annals of the New York Academy of Sciences·Andrew R Delamater, Stephen Oakeshott
Apr 6, 2007·Neuron·Thomas A StalnakerGeoffrey Schoenbaum
Apr 13, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kay M Tye, Patricia H Janak
May 4, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sean B Ostlund, Bernard W Balleine
Sep 12, 2007·Annals of the New York Academy of Sciences·Elisabeth A Murray, Alicia Izquierdo
Sep 18, 2007·Annals of the New York Academy of Sciences·Sean B Ostlund, Bernard W Balleine
Apr 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sean B Ostlund, Bernard W Balleine

❮ Previous
Next ❯

Citations

Nov 20, 2015·Frontiers in Behavioral Neuroscience·Phillip M BakerSheri J Y Mizumori
Nov 4, 2015·Frontiers in Behavioral Neuroscience·Jakob SimmankAnnette Horstmann
Mar 17, 2016·Neuroscience·Alicia IzquierdoAndrew Holmes
Apr 20, 2016·Behavioural Brain Research·Alicia IzquierdoAlexandra Stolyarova
Aug 17, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Stéphane PotvinAdrianna Mendrek
Nov 20, 2016·The European Journal of Neuroscience·Nina T Lichtenberg, Kate M Wassum
Dec 16, 2016·The European Journal of Neuroscience·Evan E Hart, Alicia Izquierdo
Sep 3, 2016·Developmental Neurobiology·Lydia OikonomidisAngela C Roberts
Mar 30, 2017·Nature Neuroscience·Bruno B Averbeck, Vincent D Costa
Dec 7, 2017·Frontiers in Psychology·Manuela SchuetzeSigne Bray
Oct 31, 2018·Behavioural Pharmacology·Jacqueline-Marie N FerlandCatharine A Winstanley
Oct 31, 2018·Genes, Brain, and Behavior·Ali GhobbehJohn A Wemmie
May 31, 2019·Nature Reviews. Neuroscience·Alireza Soltani, Alicia Izquierdo
Oct 21, 2018·Cognitive, Affective & Behavioral Neuroscience·Caitlin A OrsiniBarry Setlow
Aug 15, 2019·The Australian and New Zealand Journal of Psychiatry·Imke Lj Lemmers-JansenLydia Krabbendam
Mar 3, 2020·Frontiers in Behavioral Neuroscience·Sara E KeeferDonna J Calu
Aug 26, 2020·Nature Reviews. Neuroscience·Katalin M Gothard
Nov 8, 2018·Psychopharmacology·Anna B Konova, Rita Z Goldstein
Jul 28, 2020·Frontiers in Behavioral Neuroscience·Ausaf A BariNader Pouratian
Feb 25, 2017·PLoS Biology·Trevor T-J ChongMasud Husain
May 11, 2019·Molecular Neurobiology·Suchan ChangHee Young Kim
Mar 22, 2020·Communications Biology·Elvi Gil-LievanaFederico Bermúdez-Rattoni
Mar 25, 2017·Social Cognitive and Affective Neuroscience·Katherine S DammeRobin Nusslock
Apr 10, 2018·Frontiers in Behavioral Neuroscience·John D SalamoneRose Presby
Feb 16, 2019·Psychology, Crime & Law : PC & L·Keith J Yoder, Jean Decety
Jul 14, 2020·Frontiers in Neuroscience·Kyna-Anne ConnJames P Kesby

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.