PMID: 9529608Apr 8, 1998Paper

The Bcl-2 family and cell death regulation

Current Opinion in Genetics & Development
K Newton, A Strasser

Abstract

Members of the Bcl-2 protein family fall into two categories on the basis of their ability to either promote or suppress apoptosis. Recent findings have linked these proteins to caspases, the cysteine proteases that effect the collapse of the cell via binding to CED-4. It seems that Bcl-2 proteins influence cell survival by regulating the activation of key caspases.

References

Dec 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P MonaghanM F Greaves
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M KozopasR W Craig
Apr 20, 1995·Nature·T ChittendenB C Guild
May 1, 1994·Bio/technology·P J Barr, L D Tomei
Aug 1, 1994·Current Opinion in Genetics & Development·M O Hengartner, H R Horvitz
Mar 11, 1994·Cell·D L VauxA Strasser
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·S HendersonA Rickinson
Oct 1, 1996·The Journal of Experimental Medicine·S A SusinG Kroemer
Nov 15, 1996·Genes & Development·K WangS J Korsmeyer
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·J XiangS J Korsmeyer
Jan 2, 1997·Nature·H Duan, V M Dixit
Jan 23, 1997·Nature·A J MinnC B Thompson
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·E H ChengJ M Hardwick

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Citations

Feb 5, 2010·Apoptosis : an International Journal on Programmed Cell Death·Chien-Li ChiuJiann-Ruey Hong
Jan 1, 2003·Journal of Neuroimmunology·M K ShariefM A Noori
Nov 20, 1998·Trends in Genetics : TIG·M M MetzsteinH R Horvitz
Sep 19, 2003·Seminars in Nephrology·Gur P Kaushal
Jun 6, 2003·Progress in Neurobiology·L Lossi, A Merighi
Jun 30, 2000·Endocrinology and Metabolism Clinics of North America·E PhelpsJ R Baker
Apr 26, 2002·Current Opinion in Immunology·David A HildemanPhilippa Marrack
Jul 17, 2001·Clinical Endocrinology·J D Bretz, J R Baker
May 4, 1999·Clinical and Experimental Pharmacology & Physiology·S Kumar
Sep 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M K ShariefY K Semra
Aug 30, 2001·Thyroid : Official Journal of the American Thyroid Association·S H WangJ R Baker
Nov 21, 2008·Antioxidants & Redox Signaling·Joya Chandra
Aug 25, 2000·Thyroid : Official Journal of the American Thyroid Association·F F PalazzoR Mirakian
Mar 6, 2003·The Journal of Clinical Investigation·David A HildemanPhilippa Marrack
Oct 3, 2003·Ageing Research Reviews·Jian-Hua ZhangBrian Herman
Dec 11, 2007·Journal of Theoretical Biology·Noriaki OkazakiHiroshi Chuman
Apr 11, 2012·Journal of Neuroscience Research·Xinjing LuoHaixiao Chen
Jul 5, 2005·The Veterinary Journal·L LossiA Merighi
Dec 8, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Li-Li JiZheng-Tao Wang
Jul 18, 2002·Immunity·David A HildemanPhilippa Marrack
Dec 4, 2014·Molecular Immunology·Víctor H OlavarríaAlejandro Yáñez
Dec 23, 2000·The Journal of Urology·R N CoffeyJ M Fitzpatrick

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