The beginning of connectomics: a commentary on White et al. (1986) 'The structure of the nervous system of the nematode Caenorhabditis elegans'

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Scott W Emmons

Abstract

The article 'Structure of the nervous system of the nematode Caenorhabditis elegans' (aka 'The mind of a worm') by White et al., published for the first time the complete set of synaptic connections in the nervous system of an animal. The work was carried out as part of a programme to begin to understand how genes determine the structure of a nervous system and how a nervous system creates behaviour. It became a major stimulus to the field of C. elegans research, which has since contributed insights into all areas of biology. Twenty-six years elapsed before developments, notably more powerful computers, made new studies of this kind possible. It is hoped that one day knowledge of synaptic structure, the connectome, together with results of many other investigations, will lead to an understanding of the human brain. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.

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Citations

Jul 26, 2016·Frontiers in Neuroanatomy·Shawn Mikula
Jul 22, 2016·Annual Review of Neuroscience·Larry W Swanson, Jeff W Lichtman
Dec 2, 2017·Genes, Brain, and Behavior·D G AshbrookR W Williams
Jun 13, 2018·Annual Review of Analytical Chemistry·Farhan Kamili, Hang Lu
Jan 13, 2018·Nature·Scott W Emmons
May 14, 2020·Journal of Neurophysiology·Tyler R SizemoreAndrew M Dacks
Aug 19, 2020·Journal of Neurogenetics·Andrea Cuentas-Condori, David M Miller Rd
Sep 12, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andrey PalyanovStephen D Larson
Aug 10, 2018·Personality Neuroscience·Sebastian MarkettMartin Reuter
Sep 12, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Harris S KaplanManuel Zimmer
Sep 12, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Stephen D LarsonAndré E X Brown
Jul 21, 2017·Frontiers in Human Neuroscience·Yvonne HöllerEugen Trinka
Nov 25, 2016·Frontiers in Neuroanatomy·J Leonie CazemierPaul H E Tiesinga
Jul 19, 2016·Micromachines·Bhagwati P Gupta, Pouya Rezai

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Methods Mentioned

BETA
electron microscopy
dissecting
transgenic

Software Mentioned

Modular I

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