The Beginning of the End: Initial Steps in the Degradation of Plasma Membrane Proteins.

Frontiers in Plant Science
Maximilian Schwihla, Barbara Korbei

Abstract

The plasma membrane (PM), as border between the inside and the outside of a cell, is densely packed with proteins involved in the sensing and transmission of internal and external stimuli, as well as transport processes and is therefore vital for plant development as well as quick and accurate responses to the environment. It is consequently not surprising that several regulatory pathways participate in the tight regulation of the spatiotemporal control of PM proteins. Ubiquitination of PM proteins plays a key role in directing their entry into the endo-lysosomal system, serving as a signal for triggering endocytosis and further sorting for degradation. Nevertheless, a uniting picture of the different roles of the respective types of ubiquitination in the consecutive steps of down-regulation of membrane proteins is still missing. The trans-Golgi network (TGN), which acts as an early endosome (EE) in plants receives the endocytosed cargo, and here the decision is made to either recycled back to the PM or further delivered to the vacuole for degradation. A multi-complex machinery, the endosomal sorting complex required for transport (ESCRT), concentrates ubiquitinated proteins and ushers them into the intraluminal vesicles of mul...Continue Reading

References

Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B M Pearse
Nov 15, 1996·The Journal of Biological Chemistry·F TebarT Kirchhausen
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·N RingstadP De Camilli
Jan 29, 2003·The Journal of Biological Chemistry·Kristi G BacheHarald Stenmark
Mar 26, 2003·Annual Review of Biochemistry·Juan S Bonifacino, Linton M Traub
May 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Bo ShenOdd-Arne Olsen
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Linda Hicke, Rebecca Dunn
Dec 6, 2003·Journal of Cell Science·Valerie Legendre-GuilleminPeter S McPherson
Aug 18, 2004·The Journal of Cell Biology·John McCulloughSylvie Urbé
Oct 6, 2004·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Takeshi TennoMasahiro Shirakawa
Oct 12, 2004·Cell Biochemistry and Biophysics·Nicholas B Miliaras, Beverly Wendland
Jan 14, 2005·Current Topics in Microbiology and Immunology·S SigismundP P Di Fiore
May 11, 2005·Traffic·Alessandra d'AzzoTommaso Nastasi
Oct 18, 2005·Molecular and Cellular Biology·Takashi MitsunariHiroshi Ohno
Jan 24, 2006·Nature Cell Biology·Daniela HoellerIvan Dikic
Feb 21, 2006·Trends in Plant Science·Verena Winter, Marie-Theres Hauser
Feb 25, 2006·Traffic·Matthew J HawrylukLinton M Traub
Mar 3, 2006·Genes & Development·Silke RobatzekThomas Boller
Sep 26, 2006·Trends in Cell Biology·Michael J Clague, Sylvie Urbé
Nov 9, 2006·Development·Christoph SpitzerMartin Hülskamp
Feb 20, 2007·Current Biology : CB·Pankaj DhonuksheJirí Friml
May 10, 2007·Traffic·Evan Eisenberg, Lois E Greene
Jun 26, 2007·The Plant Cell·Xiao-Jun YinAndreas Bachmair
Jan 29, 2008·Current Opinion in Cell Biology·James H Hurley
May 27, 2008·The Plant Cell·Catherine A KonopkaSebastian Y Bednarek
Jun 13, 2008·The Plant Journal : for Cell and Molecular Biology·Maya BarAdi Avni
Aug 6, 2008·Plant Physiology·David G RobinsonKarin Schumacher
Aug 6, 2008·Plant Physiology·Niko Geldner, Silke Robatzek
Oct 2, 2008·Traffic·Lorenzo Frigerio, Chris Hawes
Dec 5, 2008·Traffic·Cédric BlancFrançois Letourneur

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Citations

Jan 31, 2021·Plants·Paymon Doroodian, Zhihua Hua
Mar 4, 2021·International Journal of Molecular Sciences·Bibhas AmatyaPedro A Jose
Sep 23, 2021·The Plant Cell·Fernando AnientoEugenia Russinova

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Methods Mentioned

BETA
ubiquitination
deubiquitination
immunoprecipitation
PMA
GTPases
nucleotide exchange
deubiquitinate

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