The behavioral effect of m-chlorophenylpiperazine (mCPP) and methylphenidate in first-episode schizophrenia and normal controls

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
A R KoreenM Chakos

Abstract

Although there has been renewed interest in the serotonin (5-HT) system in schizophrenia, direct evidence for 5-HT dysfunction is limited. This study compares the responses of m-chlorophenyl-piperazine (mCPP), a 5-HT agonist, in first-episode schizophrenia and a known psychotogenic dopamine agonist, methylphenidate. Eighteen patients experiencing their first episode of psychosis and eight healthy controls received methylphenidate (0.5 mg/kg) and mCPP (0.1 mg/kg) intravenously. Behavioral assessments were done before and after the procedure, and a peak response to each agent was rated. Methylphenidate, but not mCPP, produced psychotic symptoms in patients. mCPP did decrease anxiety, hallucinations, and anger and increased agitation, somatic concern, and impaired understandability. Both agents had limited effects on controls. In conclusion, unlike methylphenidate, mCPP did not produce psychotic symptom activation in schizophrenic patients in, and its effects appeared to be nonspecific.

Citations

Dec 4, 1998·Biological Psychiatry·J A LiebermanJ E Kraus
Aug 12, 2005·Journal of Child and Adolescent Psychopharmacology·Gabrielle A Carlson, Barbara Fish
Sep 11, 2013·European Psychiatry : the Journal of the Association of European Psychiatrists·S DalsgaardP H Thomsen
Mar 16, 2004·CNS Drugs·Jeffrey A Lieberman
May 9, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kyung-Heup AhnDeepak Cyril D'Souza
Oct 20, 2001·Accountability in Research·Vera Hassner Sharav
Sep 2, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Catherine CurranAndrew McBride
Jan 9, 2021·Behavioural Brain Research·Jose M RubioJohn M Kane

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