The behavioral effects of acute and chronic JL 13, a putative antipsychotic, in Cebus non-human primates

Psychopharmacology
D E CaseyJ F Liégeois

Abstract

Neuroleptic or antipsychotic drugs are the mainstay of treating acute and chronic psychosis. However, their efficacy is offset by a wide array of side effects, especially extrapyramidal syndromes (EPS). In an attempt to develop novel antipsychotic agents, several animal models have been developed to characterize the profile of new chemical entities. To evaluate the behavioral characteristics of JL 13, a potentially unique antipsychotic agent, three separate studies across a wide dose range in Cebus monkeys were conducted and compared with two studies of oral and parenteral haloperidol. Twelve Cebus monkeys were tested with single i.m. doses of JL 13 (0.1-2.5 mg/kg), single p.o. doses (1.0-50.0 mg/kg), and 35 days of continuous p.o. (up to 25 mg/kg) treatments and were blindly evaluated. The same twelve monkeys were also tested with haloperidol i.m. (0.01-0.25 mg/kg) and nine of the monkeys also received haloperidol p.o. (0.1-5.0 mg/kg). Behaviors scored included sedation/arousal, locomotor activity, EPS of parkinsonism and dystonia, as well as reactivity. JL 13 produced mild to moderate and dose-related increased sedation and decreased locomotor activity. Minimal decreases in eye blinking rates were also noted as a consequence ...Continue Reading

Citations

Sep 18, 2007·Journal of Molecular Neuroscience : MN·Frank I TaraziJean-François Liégeois
Jul 1, 2006·Journal of Neuroscience Research·Taylor Moran-GatesFrank I Tarazi
Sep 14, 2013·The Journal of Pharmacology and Experimental Therapeutics·Roger D PorsoltDavid Virley

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