PMID: 6973157Jun 1, 1981Paper

The behavioral effects of hallucinogens in rats following 5,7-dihydroxytryptamine administration into the medial forebrain bundle

Pharmacology, Biochemistry, and Behavior
R L CommissarisR H Rech

Abstract

The hypothesis that 5-hydroxytryptamine (5-HT) neurons and/or receptors are involved in the mechanism of action of hallucinogens is supported by the fact that intraventricular administration of the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) selectively destroys central 5-HT neurons in the brain and potentiates the behavioral effects of lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM) and mescaline. The locus in the brain where this potentiation might occur is not known. In the present experiment, the medial forebrain bundle (MFB) was studied because it is the primary tract containing fibers from the cell bodies in the raphe nuclei to forebrain structures receiving 5-HT input. Male rats received 5,7-DHT (6 micrograms/2 microliter) or vehicle injections bilaterally into the MFB; this procedure caused a significant reduction of 5-HT in the cortex, hippocampus and hypothalamus of lesioned rats, but not in the striatum. Regional dopamine and norepinephrine concentrations were not affected by this treatment. The behavioral effects of the hallucinogens were tested in a situation in which the animals pressed a bar under a fixed ratio-40 (FR-40) schedule of food reinforcement. The disruptive effects of LSD on ...Continue Reading

References

Feb 28, 1979·Psychopharmacology·J C Winter
Oct 1, 1980·Pharmacology, Biochemistry, and Behavior·F J WhiteJ B Appel

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Citations

Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·J W HenckR H Rech
Aug 1, 1984·Pharmacology, Biochemistry, and Behavior·D J Mokler, R H Rech
Jan 1, 1982·Neuroscience and Biobehavioral Reviews·R H Rech, R L Commissaris

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