The behavioral effects of MK-801 injected into nucleus accumbens and caudate-putamen of rats

Pharmacology, Biochemistry, and Behavior
I al-KhatibA Ulugöl

Abstract

In this study, we investigated the behavioral effects of MK-801 (1-20 micrograms) injected into the posterior parts of nucleus accumbens (ACC) and caudate-putamen (CP) in rats. Interactions of diazepam (DZP, 10 micrograms), haloperidol (HPD, 2 micrograms), and scopolamine (SCOP, 10 micrograms) with 20 micrograms of MK-801 were also studied. All injections were done in 2 microliters. In ACC, MK-801 increased locomotion, rearing, and head shakes. The effect of MK-801 especially at 20 micrograms was accompanied by a motor syndrome: head weaves, circling, body rolls, and ataxia. DZP nonsignificantly reduced the locomotion but it significantly (p < 0.05) reduced head shakes, weaves, circling, and body rolls produced by MK-801. HPD reduced grooming and head shakes. SCOP potentiated MK-801 hyperlocomotion, whereas it decreased body rolls, head shakes, and weaves. In CP, MK-801 increased locomotion, but less than in ACC (p < 0.05). The effect of MK-801 was significantly increased by SCOP. MK-801 also increased grooming (reduced by HPD and increased by SCOP) and at 5-20 micrograms induced oral movements that were decreased by HPD. These results indicate that the posterior part of ACC is involved in MK-801 hyperlocomotion and motor syndr...Continue Reading

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Citations

Apr 8, 1999·European Journal of Pharmacology·K Frantz, C Van Hartesveldt
Apr 17, 1999·European Journal of Pharmacology·K Frantz, C Van Hartesveldt
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Michael F PrestiMark H Lewis
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Jul 31, 1999·Journal of Neurochemistry·B D Kretschmer

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