PMID: 8970825Sep 15, 1996Paper

The behavioral salience of tones as indicated by prepulse inhibition of the startle response: relationship to hearing loss and central neural plasticity in C57BL/6J mice

Hearing Research
S Carlson, J F Willott

Abstract

Adult C57BL/6J mice exhibit high-frequency, sensorineural hearing loss accompanied by physiological changes in the upper auditory brainstem and cortex, referred to as hearing-loss induced (HLI) plasticity: as high-frequency sensitivity declines, many neurons come to respond better to still-audible, middle-frequency tones (especially 12-16 kHz). We used prepulse inhibition (PPI) to assess the relationship between the behavioral salience of tones and HLI plasticity. The ability of a tone 'prepulse' (S1), presented 100 ms before a startle-eliciting tone (S2), to 'inhibit' startle responses was measured in normal-hearing 1-month-olds and 5-month-olds with high-frequency hearing loss. Tone bursts of 4, 8, 12, 16, and 24 kHz were used as S1s and S2s in all possible combinations. PPI was significantly improved (more inhibition) in 5-month-olds with 12 or 16 kHz S1s. This effect was not influenced by S2 frequency or the size of the startle evoked by S2-only stimuli (smaller for high-frequency S2s in older mice). The increased salience of 12-16 kHz S1s in 5-month-old C57 mice parallels changes in the central representation of tone frequency and implies a behavioral effect of HLI plasticity.

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Citations

Jun 5, 2003·Journal of the Association for Research in Otolaryngology : JARO·James R Ison, Paul D Allen
Sep 8, 2010·Journal of the Association for Research in Otolaryngology : JARO·Gareth P JonesAndrei N Lukashkin
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Feb 24, 1998·Hearing Research·J F WillottW A Falls
Aug 23, 2003·Behavioral Neuroscience·James F WillottLeona Gagnon
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Jul 12, 2008·Genes, Brain, and Behavior·Gregory A TaylorWilliam C Wetsel
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gloria I PerezJonathan L Tilly
Jun 16, 2011·Journal of Neuroscience Methods·Amanda ClauseKarl Kandler
Nov 17, 2009·Behavioural Brain Research·Sandra L McFaddenRussell E Morgan
Aug 8, 2009·Physiology & Behavior·Bernhard H GaesePeter K D Pilz
Jul 15, 2015·Journal of Neuroscience Methods·Calum A GrimsleyAlexander V Galazyuk
Sep 10, 2014·Behavioural Brain Research·Nathanael J YatesJennifer Rodger
Dec 12, 2002·Molecular Psychiatry·M A GeyerR Paylor
Jul 17, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anneloes DirksBerend Olivier
Feb 20, 2009·Psychophysiology·Frauke NeesHartmut Schächinger
Nov 12, 2019·Frontiers in Systems Neuroscience·Maryse E ThomasÉtienne de Villers-Sidani
Apr 1, 2018·Hearing Research·Ryan J LongeneckerAlexander V Galazyuk

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