PMID: 11323126Apr 27, 2001Paper

The behavioural importance of dynamically activated descending inhibition from the nucleus reticularis gigantocellularis pars alpha

Pain
John AzamiR Monhemius

Abstract

We have recently demonstrated (J Physiol 506 (1998) 459) that the dynamic activation of descending inhibition of the nociceptive response of spinal multireceptive cells occurs in the nucleus reticularis gigantocellularis pars alpha (GiA). In the same paper we have shown that Lamina I dorsal horn cells are responsible for activating this inhibition via a pathway which runs in the contralateral dorsolateral funiculus. The effects of dynamically activating this system by noxious stimulation on behavioural responses to noxious stimuli have not been established. Here we demonstrate the effects of GiA on the behavioural response during application of standardized noxious stimuli. As this system is activated in response to noxious stimulation (J Physiol 506 (1998) 459), it is possible that chronic pain states may also activate GiA. We have therefore investigated this possibility in animals following partial sciatic nerve ligation (an animal model of chronic pain; Pain 43 (1990) 205). Male Wistar rats (280-310 g) were anaesthetized with halothane (0.5-2% in O(2)). Guide cannulae for microinjections were stereotaxically placed above GiA. In one group of animals the sciatic nerve was partially ligated. Animals were allowed to recover for...Continue Reading

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Citations

Jul 5, 2003·Behavioural Brain Research·Catherine BielajewEleftherios Milairessis
May 30, 2002·Progress in Neurobiology·Mark J Millan
Jan 17, 2009·Brain Research Reviews·M M HeinricherB M Lumb
Nov 22, 2013·Pain Practice : the Official Journal of World Institute of Pain·Mikwang KwonLevent Alev
Oct 27, 2004·Pharmacology, Biochemistry, and Behavior·Renato Leonardo de FreitasNorberto Cysne Coimbra
Mar 14, 2007·Pain·Cristiane Flora Villarreal, Wiliam Alves Prado
Sep 30, 2005·Journal of Neurophysiology·Wendy KincaidMary M Heinricher
Jul 8, 2008·Progress in Neurobiology·Nayef E Saadé, Suhayl J Jabbur

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