The BEIR VII Estimates of Low-Dose Radiation Health Risks Are Based on Faulty Assumptions and Data Analyses: A Call for Reassessment

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Jeffry A SiegelEdward B Silberstein

Abstract

The 2006 National Academy of Sciences Biologic Effects of Ionizing Radiation (BEIR) VII report is a well-recognized and frequently cited source on the legitimacy of the linear no-threshold (LNT) model-a model entailing a linear and causal relationship between ionizing radiation and human cancer risk. Linearity means that all radiation causes cancer and explicitly excludes a threshold below which radiogenic cancer risk disappears. However, the BEIR VII committee has erred in the interpretation of its selected literature; specifically, the in vitro data quoted fail to support LNT. Moreover, in vitro data cannot be considered as definitive proof of cancer development in intact organisms. This review is presented to stimulate a critical reevaluation by a BEIR VIII committee to reassess the validity, and use, of LNT and its derived policies.

References

Mar 1, 1992·International Journal of Radiation Biology·D C LloydC Tanzarella
Jun 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Markus LöbrichMichael Uder
Apr 1, 2015·Technology in Cancer Research & Treatment·Jeffry A Siegel, James S Welsh
Aug 6, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jeffry A SiegelBill Sacks
May 12, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jeffry A SiegelJames S Welsh

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Citations

Mar 8, 2019·JAD Reports·Frank S PratoRoderic P Beaujot
Jan 8, 2020·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Shizuyo Sutou
Oct 1, 2020·Dose-response : a Publication of International Hormesis Society·Paul A Oakley, Deed E Harrison
Feb 23, 2019·Dose-response : a Publication of International Hormesis Society·Charles W Pennington, Jeffry A Siegel
Jan 18, 2020·Radiation Protection Dosimetry·Asmah BohariSiti Norsyafiqah Mohd Mustafa
Jul 22, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Randall C Thompson, Prem Soman
Sep 24, 2020·Dose-response : a Publication of International Hormesis Society·Paul A OakleyDeed E Harrison
May 21, 2019·Clinical Nuclear Medicine·Patrick M Colletti
Jul 23, 2020·Revista española de medicina nuclear e imagen molecular·J P Suárez Fernández
Sep 27, 2019·Radiology. Imaging Cancer·Carrie B Hruska
May 15, 2021·Dento Maxillo Facial Radiology·Niels BelmansSarah Baatout
Jun 2, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·James R DuncanRichard L Wahl
Jul 22, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Charles W Pennington
Aug 4, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Joseph John Bevelacqua
Aug 4, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Mohan Doss
Aug 12, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jeffry A SiegelBennett Greenspan
Sep 1, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jeffry A SiegelMichael G Stabin
Oct 27, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jeffry A SiegelBennett S Greenspan

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