The beneficial effect of hydroxyapatite lasts: a randomized radiostereometric trial comparing hydroxyapatite-coated, uncoated, and cemented tibial components for up to 16 years.

Acta Orthopaedica
Bart G PijlsRob Ghh Nelissen

Abstract

In contrast to early migration, the long-term migration of hydroxyapatite- (HA-) coated tibial components in TKA has been scantily reported. This randomized controlled trial investigated the long-term migration measured by radiostereometric analysis (RSA) of HA-coated, uncoated, and cemented tibial components in TKA. 68 knees were randomized to HA-coated (n = 24), uncoated (n = 20), and cemented (n = 24) components. All knees were prospectively followed for 11-16 years, or until death or revision. RSA was used to evaluate migration at yearly intervals. Clinical and radiographic evaluation was according to the Knee Society system. A generalized linear mixed model (GLMM, adjusted for age, sex, diagnosis, revisions, and BMI) was used to take into account the repeated-measurement design. The present study involved 742 RSA analyses. The mean migration at 10 years was 1.66 mm for HA, 2.25 mm for uncoated and 0.79 mm for the cemented group (p < 0.001). The reduction of migration by HA as compared to uncoated components was most pronounced for subsidence and external rotation. 3 tibial components were revised for aseptic loosening (2 uncoated and 1 cemented), 3 for septic loosening (2 uncoated and 1 cemented), and 1 for instability (HA...Continue Reading

References

Mar 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K SøballeC Bünger
Mar 1, 1993·The Journal of Bone and Joint Surgery. British Volume·K SøballeC Bünger
Apr 18, 1998·The Journal of Bone and Joint Surgery. British Volume·E W MorscherU Aebi
Dec 5, 1998·The Journal of Bone and Joint Surgery. American Volume·R G NelissenP M Rozing
Aug 27, 1999·The Journal of Bone and Joint Surgery. British Volume·S OvergaardK Søballe
Feb 8, 2000·Clinical Orthopaedics and Related Research·S Toksvig-LarsenA Lindstrand
Apr 20, 2001·JAMA : the Journal of the American Medical Association·D MoherUNKNOWN CONSORT Group (Consolidated Standards of Reporting Trials)
Apr 9, 2002·Clinical Orthopaedics and Related Research·Rudolph G T Geesink
Aug 5, 2003·Clinical Orthopaedics and Related Research·P J DevereauxSalim Yusuf
Jul 29, 2005·The Journal of Bone and Joint Surgery. British Volume·M J Cross, E N Parish
Oct 1, 2005·Acta Orthopaedica·Edward R ValstarJohan Kärrholm
Nov 29, 2005·The Journal of Arthroplasty·Kazuya SugimotoYoshinori Takakura
Jul 11, 2006·Clinical Orthopaedics and Related Research·Kjell G NilssonTore Dalén
Jan 30, 2007·The Journal of Bone and Joint Surgery. British Volume·J-A Epinette, M T Manley
Apr 23, 2009·Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology·M TherboH M Schrøder
Jul 3, 2009·The Journal of Bone and Joint Surgery. American Volume·M J DunbarG P Reardon
Feb 26, 2010·Journal of Biopharmaceutical Statistics·Cynthia M DeSouzaAbdul J Sankoh
Sep 3, 2010·Acta Orthopaedica·Janie L Astephen WilsonKevin J Deluzio

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Citations

May 16, 2013·Orthopedics·Thomas E BrownKristian Bjorgul
Apr 12, 2012·Acta Orthopaedica·Edward ValstarRob Nelissen
Apr 26, 2012·Acta Orthopaedica·Bart G PijlsRob G H H Nelissen
Jul 1, 2016·Acta Orthopaedica·Anders Henricson, Kjell G Nilsson
Dec 8, 2017·The Bone & Joint Journal·M J DunbarC G Richardson
Mar 7, 2018·Acta Orthopaedica·Bart G PijlsRob G H H Nelissen
Jun 29, 2014·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·P BarbadoroS Giannini
Sep 4, 2015·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Theodore BourasPanagiotis Korovessis
Oct 27, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Anders HenricsonSead Crnalic
Feb 27, 2021·The Journal of Arthroplasty·Elise K LaendeMichael J Dunbar
Apr 23, 2021·The Journal of Bone and Joint Surgery. American Volume·Koen T van HamersveldRob G H H Nelissen

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Methods Mentioned

BETA
total hip arthroplasty
RSA
additional
delamination
the

Software Mentioned

MBRSA
R

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