The beneficial effect of interleukin-12 on arthritis induced by group B streptococci is mediated by interferon-gamma and interleukin-10 production

Arthritis and Rheumatism
Manuela PulitiLuciana Tissi

Abstract

To assess the effect of interleukin-12 (IL-12) administration on the evolution of systemic infection and septic arthritis induced by group B streptococci (GBS) in mice. CD1 mice were inoculated intravenously with arthritogenic strain 1/82 of type IV GBS. Exogenous murine IL-12 was administered intraperitoneally 18 hours or 5 days after infection with 1 x 10(7) GBS, at doses ranging from 0.5 to 2.5 microg per mouse. Mice were monitored daily for survival and for signs of arthritis. In a subsequent set of experiments, mice were killed at selected times for examination of bacterial clearance, histopathologic changes in the joints, and cytokine production. IL-12 administration before the onset of clinical signs had a beneficial effect on GBS-induced arthritis and was clearly dose-dependent. The 2.5-microg dose per mouse totally prevented death from GBS-induced arthritis. The decrease in pathology was associated with a reduction of the bacterial burden and a change in the cytokine profile. In particular, systemic and joint levels of interferon-gamma (IFN gamma) and IL-10 significantly increased in mice treated with IL-12, whereas a decrease in IL-6 and IL-1 beta production was observed. The beneficial effects of IL-12, in terms of t...Continue Reading

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Citations

Jul 26, 2011·Current Infectious Disease Reports·Sumeet Chander, Gerald Coakley
Aug 1, 2012·Current Infectious Disease Reports·Meghan B Brennan, Jennifer L Hsu
Oct 9, 2002·Cellular Microbiology·Manuela PulitiLuciana Tissi
Nov 22, 2011·Best Practice & Research. Clinical Rheumatology·Miriam García-AriasEmilio Martín Mola
Nov 21, 2014·Memórias do Instituto Oswaldo Cruz·Viviane de Oliveira Freitas LionePrescilla Emy Nagao
Jun 10, 2004·Arthritis and Rheumatism·Luciana TissiManuela Puliti
Sep 1, 2007·Expert Review of Clinical Immunology·Hyun-Dong Chang, Andreas Radbruch
Jun 11, 2021·BMC Musculoskeletal Disorders·Jian Wang, Liucai Wang

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