The beneficial effect of L-cysteine supplementation on DNA oxidation induced by forced training

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Stylianos TsakirisKleopatra H Schulpis

Abstract

Forced training is closely implicated with free radicals production and indication of tissue damage as well as DNA oxidation. To investigate the effect of L-cysteine (L-cys) supplementation on DNA oxidative damage found in basketball players after forced training. Blood was obtained from 10 players pre-game (group A), post-game (group B) and after 1 month L-cys (0.5 g 24 h(-1), orally) supplementation, pre- (group C) and post-training (group D). Total antioxidant status (TAS) and the biomarker of DNA oxidative damage 8-hydroxy-2-deoxyguanosine (8-OHdG) as well as creatine kinase (CK) and lactate dehydrogenase (LDH) were measured with commercial kits. TAS was increased in the groups with L-cys (group C and group D). Post-exercise 8-OHdG levels, CK and LDH were remarkably lower (0.16+/-0.03 ng ml(-1), 115+/-15 U l(-1), 417+/-90 U l(-1), respectively) in group D than those in group B (0.36+/-0.05 ng ml(-1), 286+/-12 U l(-1), 688+/-88U l(-1), p<0.001, respectively). 8-OH dG levels were negatively correlated with TAS(r=-0.718, p<0.01) and positively with CK levels(r=0.590, p<0.01). L-cys supplementation in basketball players may reduce DNA damage induced by training. The sulfur-containing amino acid may protect muscle cells "death" ...Continue Reading

Citations

Dec 17, 2008·The British Journal of Nutrition·Sophie TesseraudIban Seiliez
Dec 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Daniela GiustariniRanieri Rossi
Feb 6, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Christina KarpouziVassilis Mougios
Jan 15, 2008·Free Radical Biology & Medicine·Michael B Reid
Jan 11, 2014·Journal of Sports Sciences·Athanasios KabasakalisVassilis Mougios
Jan 1, 2017·Fiziolohichnyĭ zhurnal·T Yu MatvienkoYu I Prylutskyy
Dec 31, 2020·Neuropsychiatric Disease and Treatment·Yekta DowlatiJeffrey H Meyer

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