The beneficial effects of long-term enzyme replacement therapy on cardiac involvement in Japanese Fabry patients

Molecular Genetics and Metabolism
Kenichi HongoYoshikatsu Eto

Abstract

Fabry disease is a hereditary disorder that occurs due to the reduction or absence of alpha-galactosidase A activity, which leads to cardiac involvement including left ventricular hypertrophy (LVH). Enzyme replacement therapy (ERT) provides better patient outcomes by preventing serious complications. However, there have been very few studies on the long-term effects of ERT on the cardiac manifestations in Japanese Fabry patients. We retrospectively analyzed the data from the medical records of 42 Fabry patients (male, n = 17; female, n = 25) who were followed at Jikei University Hospital, and in whom the long-term effects of ERT could be evaluated (median follow-up period: male, 11 years; female, 8 years). The slope of the left ventricular mass (LVM) increase was 3.02 ± 3.41 g/m2/year in males and 1.69 ± 2.73 g/m2/year in females. In a subgroup analysis, the slopes of males with and without LVH did not differ to a statistically significant extent; however, the slope in female patients without LVH was significantly smaller than that of female patients with LVH. We then compared our data to the natural historical data that have previously been reported. In comparison to the previously reported data, we found a significant reducti...Continue Reading

Citations

Jul 9, 2020·European Journal of Heart Failure·Aleš LinhartPerry Elliott
Jun 22, 2019·Annual Review of Biochemistry·Bernadette Breiden, Konrad Sandhoff
Feb 2, 2021·Frontiers in Cardiovascular Medicine·Satoshi MorimotoKenichi Hongo

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