The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases

Laboratory Investigation; a Journal of Technical Methods and Pathology
Yan LiuRaymond Chuen-Chung Chang

Abstract

Growing evidence has shown the beneficial influence of exercise on humans. Apart from classic cardioprotection, numerous studies have demonstrated that different exercise regimes provide a substantial improvement in various brain functions. Although the underlying mechanism is yet to be determined, emerging evidence for neuroprotection has been established in both humans and experimental animals, with most of the valuable findings in the field of mental health, neurodegenerative diseases, and acquired brain injuries. This review will discuss the recent findings of how exercise could ameliorate brain function in neuropathological states, demonstrated by either clinical or laboratory animal studies. Simultaneously, state-of-the-art molecular mechanisms underlying the exercise-induced neuroprotective effects and comparison between different types of exercise will be discussed in detail. A majority of reports show that physical exercise is associated with enhanced cognition throughout different populations and remains as a fascinating area in scientific research because of its universal protective effects in different brain domain functions. This article is to review what we know about how physical exercise modulates the pathophysi...Continue Reading

References

Apr 1, 1969·Electroencephalography and Clinical Neurophysiology·C H Vanderwolf
Jul 1, 1993·Brain Research. Molecular Brain Research·L H Burgess, R J Handa
Apr 15, 1999·Annual Review of Neuroscience·L L Rubin, J M Staddon
Dec 11, 1999·Medicine and Science in Sports and Exercise·S N Blair, S Brodney
Dec 14, 1999·The European Journal of Neuroscience·H HiraseG Buzsáki
Oct 18, 2002·Gene·Andreas TeufelHeiner Westphal
Apr 4, 2003·Medicine and Science in Sports and Exercise·Dana E KingWilliam S Pearson
Jun 5, 2003·Molecular Neurobiology·Eva CarroIgnacio Torres-Aleman
Nov 14, 2003·Nature·Katrin Henze, William Martin
Dec 6, 2003·The European Journal of Neuroscience·Klaus FabelTheo D Palmer
Sep 25, 2004·Hippocampus·Eun Young SongMin Whan Jung
Mar 3, 2006·The Journal of Clinical Investigation·Brian N Finck, Daniel P Kelly
May 2, 2007·Proceedings of the National Academy of Sciences of the United States of America·Caroline GeislerGyörgy Buzsáki
Sep 4, 2007·Trends in Neurosciences·Carl W CotmanLori-Ann Christie
Nov 13, 2007·Peptides·Hung HsuchouAbba J Kastin
May 13, 2009·Journal of Neural Transmission·Arun K TiwariDaniel J Müller
Aug 12, 2009·Experimental Physiology·Peter RasmussenHenriette Pilegaard
Dec 10, 2009·Deutsches Ärzteblatt International·Carl D ReimersAnne K Reimers
Jul 21, 2010·Acta Neuropathologica·V Hugh Perry
Dec 7, 2010·Antioxidants & Redox Signaling·Gilad Twig, Orian S Shirihai
Mar 8, 2011·Journal of Psychiatric Research·Jorge Mota-PereiraJoaquim Ramos
Mar 23, 2011·Nature Biotechnology·Lydia Alvarez-ErvitiMatthew J A Wood
Jun 22, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Bruce Ovbiagele, Mai N Nguyen-Huynh
Jul 7, 2011·PloS One·Zhiping ChenMayank R Mehta
Aug 6, 2011·Journal of Applied Physiology·S BayodM Pallàs
Aug 6, 2011·Journal of Applied Physiology·Jennifer L SteinerJ Mark Davis
Oct 11, 2011·Cellular and Molecular Life Sciences : CMLS·Giuseppa MudòDan Lindholm
Nov 5, 2011·Medicine and Science in Sports and Exercise·Michel O MelanconIsabelle J Dionne
Nov 29, 2011·Progress in Neurobiology·Christian KnöchelHarald Hampel
May 9, 2012·TheScientificWorldJournal·Jose Miguel Rubio-Perez, Juana Maria Morillas-Ruiz
May 18, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Clare PuddifootGiles E Hardingham

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Citations

Jul 18, 2020·Reviews in the Neurosciences·Tommaso SchirinziLuca Marsili
Apr 8, 2020·BioResearch Open Access·Walter H MoosXiaohong Chen
Nov 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Ricardo LaranjeiroMonica Driscoll
Aug 9, 2020·Frontiers in Aging Neuroscience·Simona DanieleFerdinando Franzoni
Aug 19, 2020·Biomedicines·Andleeb KhanMuneeb U Rehman
Aug 23, 2020·International Journal of Molecular Sciences·B MahalakshmiV Bharath Kumar
Jan 19, 2021·Journal of Alzheimer's Disease : JAD·Daymara Mercerón-MartínezAdrian G Palacios
Jan 13, 2021·International Journal of Molecular Sciences·Edna SoaresFrederico C Pereira
Jan 29, 2021·Frontiers in Human Neuroscience·Julia C BassoRachel Rugh
Jan 7, 2021·International Journal of Molecular Sciences·Fanni TóthLászló Vécsei
Apr 4, 2021·International Journal of Molecular Sciences·Susana López-OrtizAlejandro Santos-Lozano
Apr 12, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Masoud RahmatiFarzaneh Chehelcheraghi
May 1, 2021·International Journal of Molecular Sciences·Kévin NayJohn W Scott
May 13, 2021·Neurorehabilitation and Neural Repair·Rebekah L S SummersColum D MacKinnon

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