The beneficial effects of the herbal medicine Free and Easy Wanderer Plus (FEWP) and fluoxetine on post-stroke depression

The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy
Lian-Tao LiMei Yu

Abstract

Depression occurs frequently in post-stroke patients and appears to be associated with impairment of their rehabilitation and functional recovery. In this study, we evaluated the efficacy and tolerability of the herbal drug, Free and Easy Wanderer Plus (FEWP), in patients affected by post-stroke depression (PSD). One hundred fifty (150) moderately to severely depressed patients as determined by a score >20 on the Hamilton Depression Scale (HDS) after a single ischemic or hemorrhagic stroke were randomly divided into the FEWP group (n = 60), the fluoxetine group (n = 60), and the placebo group (n = 30). The FEWP, fluoxetine, and placebo were administered to the patients over a period of 8 weeks. Depression was evaluated by HDS and the Barthel Index (BI) before, during, and after the treatment. Significantly higher clinical response rates were observed in both the FEWP and fluoxetine groups compared to the placebo group (60% and 65.5% versus 21.4%, chi(2) = 15.9, p < 0.01) and there was no difference in the response rates between the FEWP group and the fluoxetine group at the end of this study (60% versus 65.5%, chi(2) = 0.38, p > 0.05). Compared to fluoxetine, FEWP produced significantly greater improvement in depression at week...Continue Reading

References

Aug 17, 1992·The Medical Journal of Australia·P L MorrisR G Robinson
Aug 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·D T WadeR A Hewer
Sep 1, 1982·Stroke; a Journal of Cerebral Circulation·R G Robinson, T R Price
Jan 1, 1994·The American Journal of Chinese Medicine·L D ZhangS B Jin
Jun 1, 1994·Stroke; a Journal of Cerebral Circulation·G AndersenL Lauritzen
Oct 1, 1993·Stroke; a Journal of Cerebral Circulation·F AngeleriG Nolfe
Jan 1, 1993·The American Journal of Psychiatry·P L MorrisT R Price
Jan 1, 1995·International Psychogeriatrics·J L Gonzalez-TorrecillasA Lobo
Nov 18, 1998·Archives of General Psychiatry·A H WongH S Boon
Aug 6, 2000·Stroke; a Journal of Cerebral Circulation·L WiartM Barat
Sep 6, 2000·Psychiatric Services : a Journal of the American Psychiatric Association·G Beaubrun, G E Gray
Feb 7, 2001·The American Journal of Psychiatry·R C KesslerD M Eisenberg
Aug 13, 2002·Journal of Clinical Psychopharmacology·Kazuo Yamada, Shigenobu Kanba
Dec 18, 2002·Psychiatry and Clinical Neurosciences·Naoki MantaniKatsutoshi Terasawa
Feb 1, 2003·Biological Psychiatry·Jonathan R T DavidsonMalcolm N McLeod
Jun 18, 2003·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·B Y H LamN J Sucher
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Apr 20, 2005·Drug Discovery Today·Albert AdellFrancesc Artigas
Nov 5, 2005·Toxicon : Official Journal of the International Society on Toxinology·Dan-Qing LiLi-Jia An
May 26, 2006·Acta Pharmacologica Sinica·Xian-Fang MengChun Zhang
Dec 19, 2006·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chang-Suo LiuJun-Tian Zhang
May 22, 2007·European Journal of Pharmacology·Yuan-Yuan TianYong-Ming Bao
Sep 22, 2007·The International Journal of Biochemistry & Cell Biology·Lin-Lin TianSheng-Qi Wang

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Citations

Jan 20, 2012·Journal of General Internal Medicine·Claire J CreutzfeldtMelanie Walker
Apr 2, 2014·Lancet Neurology·Maree L HackettGillian E Mead
Mar 12, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Lee Butler, Karen Pilkington
Aug 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Hua-Ning WangZhang-Jin Zhang
Nov 19, 2011·Journal of Clinical Nursing·Pamela van der RietKannapatch Srithong
Nov 7, 2012·Forschende Komplementärmedizin = Research in Complementary Medicine·Sabine D KleinUrsula Wolf
Nov 16, 2012·The Cochrane Database of Systematic Reviews·Gillian E MeadMaree L Hackett
Jan 31, 2013·Stroke; a Journal of Cerebral Circulation·Gillian E MeadMaree Hackett
Nov 27, 2019·The Cochrane Database of Systematic Reviews·Lynn A LeggGillian E Mead
Jan 29, 2020·The Cochrane Database of Systematic Reviews·Sabine AllidaMaree L Hackett
Jun 9, 2016·Geriatrics & Gerontology International·Shin Takayama, Koh Iwasaki
Dec 21, 2019·Expert Review of Neurotherapeutics·Luis Castilla-GuerraMiguel Angel Colmenero-Camacho
May 10, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·B QinM X Yang
Nov 16, 2021·The Cochrane Database of Systematic Reviews·Lynn A LeggGillian E Mead

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