The benefits and risks of amniocentesis for the assessment of fetal lung maturity.

British Journal of Obstetrics and Gynaecology
R M RomeS C Simmons

Abstract

Amniocentesis for estimation of the lecithin: sphingomyelin (L/S) ratio was performed on 483 patients on 552 occasions. The introduction of this test has been associated with a highly significant (p less than 0-001) decrease of 59 per cent in the incidence of respiratory distress syndrome. The finding of a low L/S ratio (less than 2-0) enabled delivery to be deferred until lung maturity had been reached in 43 (10-3 per cent) of the 419 patients who had successful amniocentesis. Fetal death occurred after amniocentesis in two patients (0-41 per cent). One fetus died after haemorrhage occurred behind an anterior placenta and the other died of exsanguination. Failed amniocentesis occurred in 64 patients (13-2 per cent), and was more common when the placenta was anterior or was not located before the procedure and when fetal growth was retarded. Fetal distress in labour occurred more commonly after failed amniocentesis. Spontaneous labour followed amniocentesis in 47 patients (9-7 per cent) and was significantly more prone to occur after 38 weeks gestation. Rhesus isoimmunization did not occur in any of the rhesus-negative patients who delivered rhesus-positive babies and who were screened six or more months after amniocentesis, al...Continue Reading

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Citations

Jul 1, 1991·Equine Veterinary Journal·A R SchmidtF J Derksen
Apr 8, 1978·British Medical Journal·H B MeireR A Wilkins
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Nov 29, 1975·British Medical Journal
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Jul 29, 1977·Archiv für Gynäkologie·F Kubli
May 1, 1978·Annals of Clinical Biochemistry·D D WoodmanU Hatch

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