The Benefits of Exercise on Structural and Functional Plasticity in the Rodent Hippocampus of Different Disease Models

Brain Plasticity
Anna R PattenB R Christie

Abstract

In this review, the benefits of physical exercise on structural and functional plasticity in the hippocampus are discussed. The evidence is clear that voluntary exercise in rats and mice can lead to increases in hippocampal neurogenesis and enhanced synaptic plasticity which ultimately result in improved performance in hippocampal-dependent tasks. Furthermore, in models of neurological disorders, including fetal alcohol spectrum disorders, traumatic brain injury, stroke, and neurodegenerative disorders including Alzheimer's, Parkinson's and Huntington's disease exercise can also elicit beneficial effects on hippocampal function. Ultimately this review highlights the multiple benefits of exercise on hippocampal function in both the healthy and the diseased brain.

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Citations

Oct 13, 2017·Physiology·Carmen Vivar, Henriette van Praag
Sep 27, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lianne J TrigianiEdith Hamel
Dec 24, 2019·Frontiers in Aging Neuroscience·Cindy K BarhaTeresa Liu-Ambrose
Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Dinair Pamplona-SantosRafael Rodrigues Lima
May 13, 2017·Cold Spring Harbor Perspectives in Medicine·C'iana CooperHenriette van Praag
Oct 9, 2015·Brain Plasticity·Henriette van Praag, Brian Christie
Jan 11, 2020·Journal of Sport and Health Science·Shanshan GuoTiemin Liu

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Methods Mentioned

BETA
transgenic

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