The benefits of respective and combined use of green tea polyphenols and ERK inhibitor on the survival and neurologic outcomes in cardiac arrest rats induced by ventricular fibrillation

The American Journal of Emergency Medicine
Xiaojun ZhuoMeng-Hua Chen

Abstract

Cerebral injury is a main factor contributing to a high mortality after cardiac arrest (CA)/cardiopulmonary resuscitation (CPR). We sought to evaluate the effect of green tea polyphenols (GTPs) and ERK1/2 inhibitor PD98059 (PD) on the survival and neurologic outcomes after CA/CPR in rats. First, rats were subjected to CA after CPR. The rats that restored spontaneous circulation were blindly allocated to the saline group (saline, IV, n = 12), the GTP group (GTPs, 10 mg/kg, IV, n = 12), the PD group (PD, 0.3 mg/kg, IV, n = 12), and the GTPs + PD group (GTPs, 10 mg/kg; PD, 0.3 mg/kg, IV, n = 12). Another 12 rats without experiencing CA and CPR were served as a sham group. Survival and the neurologic deficit score were observed for 72 hours after restoration of spontaneous circulation. Second, same experimental procedures were performed, and in 1 of 5 groups, animals were divided into 4 subgroups further according to the different time points (12, 24, 48, and 72 hours after restoration of spontaneous circulation [ROSC], n = 6/group). Brain tissues were harvested at relative time points for the morphologic evaluation as well as reactive oxygen species (ROS), malonylaldehyde, and superoxide dismutase (SOD) measurement. Green tea poly...Continue Reading

References

Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·A AlessandriniJ V Bonventre
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·S NamuraA Alessandrini
Aug 3, 2002·The European Journal of Neuroscience·Faina Kuperstein, Ephraim Yavin
Sep 18, 2002·Journal of Applied Physiology·Lei SongTommaso Pellis
Oct 31, 2002·Cancer Letters·Hirota FujikiKei Nakachi
Jul 4, 2007·The American Journal of Emergency Medicine·Meng-Hua ChenShu-Rong Mo
Feb 3, 2009·Cell Biochemistry and Biophysics·Nathan R Perron, Julia L Brumaghim
May 6, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Robert SucherJakob Troppmair
Jul 3, 2010·Journal of the American College of Nutrition·Arpita BasuTimothy J Lyons
Apr 17, 2014·International Journal of Molecular Medicine·Hua YouWei-Jing Zhang
Jul 11, 2014·Resuscitation·Jimena Del CastilloUNKNOWN Iberoamerican Pediatric Cardiac Arrest Study Network RIBEPCI

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.