PMID: 6111420Jan 1, 1981Paper

The beta-adrenergic receptor and its mode of coupling to adenylate cyclase

CRC Critical Reviews in Biochemistry
A Levitzki

Abstract

The article first includes a discussion on the classification of catecholamine receptors followed by a discussion on the binding studies of beta-receptors and their affinity labeling. Next a brief discussion on the solubilization and the current attempts to purify the receptor is presented. A large section is then devoted to the mode of coupling between beta-receptors and cyclase where much space is devoted to the role of GTP and of the membrane matrix. The review ends with a discussion on beta-receptor desensitization, supersensitivity, and the "spare receptor" concept.

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Citations

Nov 1, 1992·European Journal of Haematology·T MäkiK K Kontula
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Jun 29, 2004·Pulmonary Pharmacology & Therapeutics·K Racké, S Matthiesen

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