The beta-endorphin inhibition of mitogen-induced splenocytes proliferation is mediated by central and peripheral paracrine/autocrine effects of the opioid

Journal of Neuroimmunology
A E PaneraiP Sacerdote

Abstract

In this study we show that the opioid peptide beta-endorphin exerts a tonic inhibitory effect on the proliferative response of splenocytes to the polyclonal mitogen phytohemoagglutinin throughout two separate sites of action: one central and one peripheral. The intracerebroventricular administration of beta-endorphin, in fact, induces a significant inhibition of splenocyte proliferation. In contrast, both the intracerebroventricular and the peripheral administration of anti-beta-endorphin gamma globulins induce a significant increase in proliferation. Moreover, an increase of splenocyte proliferation was observed also after the intravenous administration of gamma globulins and intraperitoneal naloxone, and this effect was still present in hypophysectomized rats. The data reported suggest that beta-endorphin exerts a tonic inhibitory effect on proliferation, acting centrally, and peripherally throughout a paracrine/autocrine mechanism. FACS experiments show that the effect observed is not the consequence of an alteration of lymphocyte trafficking induced by the opioid.

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Citations

Sep 23, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ali G KarajiClaire Gavériaux-Ruff
Sep 6, 2003·General and Comparative Endocrinology·C B Ganesh, H N Yajurvedi
Jul 5, 2001·Physiology & Behavior·A BartolomucciS Parmigiani
May 20, 1998·Pharmacology, Biochemistry, and Behavior·Y ShavitR Yirmiya
Nov 30, 2002·Journal of Neuroimmunology·Damian RefojoEduardo Arzt
Dec 31, 1997·Journal of Neuroimmunology·R IentileG Piedimonte
Jul 17, 1999·Journal of Neuroimmunology·P SacerdoteA E Panerai
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Jun 1, 1997·British Journal of Pharmacology·P SacerdoteA E Panerai
Sep 16, 1998·Clinical and Experimental Immunology·P SacerdoteA E Panerai
May 3, 2003·The Journal of Clinical Investigation·David PhilippePierre Desreumaux
Feb 26, 2004·Arthritis Research & Therapy·I-Chuan ChuangLin-Cheng Yang
Jul 5, 1996·Regulatory Peptides·P SacerdoteA E Panerai
Nov 7, 2008·Journal of Zhejiang University. Science. B·Yong-Min LiuQing-Lian Chen
Oct 25, 2011·Experimental Parasitology·Ali Gorgin Karaji, Yazdan Hamzavi
Jul 9, 2010·International Immunopharmacology·Gabriele CampanaWilliam Raffaeli
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Jan 6, 2021·International Journal of Molecular Sciences·Alexander PilozziXudong Huang

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