The beta-subunit composition of nicotinic acetylcholine receptors in the neurons of the guinea pig inferior mesenteric ganglion

Neuroscience Letters
Olga M KovalVladimir I Skok

Abstract

The antibodies against synthetic (183-192) fragments of beta2- and beta4-subunits of rat neuronal nicotinic acetylcholine receptor were used to study a beta-subunit composition of nicotinic receptors in the inferior mesenteric ganglion of the guinea pig by both immunocytochemical staining and blocking of excitatory postsynaptic potentials induced by electric stimulation of the pre-ganglionic nerve (intermesenteric trunk). The beta4-specific antibody stained 59.8 +/- 7.5% of neurons and inhibited the synaptic responses in all (n = 10) neurons studied by 25.5 +/- 1.8%. The beta2-specific antibody did not stain ganglionic neurons and did not affect the synaptic transmission. Taking into account the previously obtained data on the alpha-subunits found in this ganglion, it is concluded that the neurons of inferior mesenteric ganglion contain nicotinic receptors of alpha3(alpha5)beta4 subtypes involved in synaptic transmission through the intermesenteric tract.

References

Jan 1, 1991·Trends in Pharmacological Sciences·E S DenerisR Duvoisin
Oct 1, 1967·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A El-Badawi, E A Schenk
Aug 16, 2001·Trends in Biochemical Sciences·T Grutter, J P Changeux
May 31, 2002·Autonomic Neuroscience : Basic & Clinical·Vladimir I Skok

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Citations

Nov 26, 2009·Immunology Letters·Olena LykhmusMaryna Skok
Mar 26, 2016·Frontiers in Molecular Neuroscience·Olena LykhmusMaryna Skok
Jun 21, 2005·European Journal of Pharmacology·Marina SkokJean-Pierre Changeux
Jun 1, 2014·The International Journal of Biochemistry & Cell Biology·Olena LykhmusMaryna Skok
Jul 15, 2015·Polish Journal of Veterinary Sciences·W SienkiewiczJ Kaleczyc
Sep 29, 2017·Frontiers in Cellular Neuroscience·Olena LykhmusMaryna Skok
Jun 29, 2018·Frontiers in Pharmacology·Kateryna UspenskaMaryna Skok
Feb 13, 2021·International Journal of Environmental Research and Public Health·Lola Rueda RuzafaArik J Hone

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