PMID: 7536811May 1, 1995Paper

The beta-subunit of Caenorhabditis elegans avermectin receptor responds to glycine and is encoded by chromosome 1

Journal of Neurochemistry
D L LaughtonA J Wolstenholme

Abstract

A full-length cDNA encoding the beta subunit of the recently described avermectin receptor was amplified from Caenorhabditis elegans mRNA. When this cDNA was injected into Xenopus oocytes a dose-dependent response to glycine was observed, together with a smaller response to 1 mM GABA. The EC50 of the glycine response was similar to that described previously for glutamate (0.38 mM). Hybridisation of the cDNA to polytene filters identified three yeast artificial chromosome clones that gave a positive signal, Y37B3, Y38E5, and Y24C9, all of which are mapped to chromosome 1. Hybridisation to a series of cosmid clones covering this area further mapped the gene encoding this subunit to the region -2,818 to -2,824.

Citations

Jan 1, 1996·Parasitology·D P ThompsonT G Geary
Jul 18, 2002·Nature Reviews. Drug Discovery·Valérie Raymond, David B Sattelle
Jan 1, 1996·Parasitology·N Sangster
Apr 13, 2019·Cell and Tissue Research·Linda A HufnagelGabriele Kass-Simon
Feb 28, 2002·The European Journal of Neuroscience·P PierobonA Concas
Oct 1, 1996·Molecular Neurobiology·T A Cleland
Jul 28, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·R D RuggieriG Kass-Simon

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