PMID: 9533821Jun 1, 1997Paper

The beta2- and beta3-adrenoceptor-mediated relaxation induced by isoprenaline and salbutamol in guinea pig taenia caecum

Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
Katsuo KoikeI Takayanagi

Abstract

To understand the receptor subtypes responsible for beta-adrenoceptor-mediated relaxation of guinea pig taenia caecum, we investigated the effects of isoprenaline and salbutamol. Isoprenaline and salbutamol caused dose-dependent relaxation of the guinea pig taenia caecum. Propranolol, bupranolol and butoxamine produced shifts of the concentration response curves for isoprenaline and salbutamol. Schild regression analyses carried out for propranolol against isoprenaline and salbutamol gave pA2 values of 8.43 and 8.88, respectively. Schild regression analyses carried out for butoxamine against isoprenaline and salbutamol gave pA2 values of 6.46 and 6.68, respectively. Schild regression analyses carried out for bupranolol against isoprenaline and salbutamol gave pA2 values of 8.60 and 8.69, respectively. However, in the presence of 3 x 10(-4) M atenolol, 10(-4) M butoxamine and 10(-6) M phentolamine to block the beta1-, beta2- and alpha-adrenoceptor effects, respectively, Schild regression analyses carried out for bupranolol against isoprenaline and salbutamol gave pA2 values of 5.77 and 5.97, respectively. These results suggest that the relaxant responses to isoprenaline and salbutamol in the guinea pig taenia caecum are mediated...Continue Reading

Citations

May 22, 2002·European Journal of Pharmacology·Takahiro Horinouchi, Katsuo Koike
Jun 1, 2000·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Y Yamamoto, K Koike
Feb 25, 2003·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yurie AkimotoKatsuo Koike
Oct 24, 2003·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yurie AkimotoKatsuo Koike
Jul 12, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshio TanakaKatsuo Koike
May 18, 2004·European Journal of Pharmacology·Katsuo KoikeYoshio Tanaka
Mar 16, 2018·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Daisuke ChinoYoshio Tanaka
Apr 5, 2001·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·T Horinouchi, K Koike

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