The beta2-adrenergic receptor is a potential prognostic biomarker for human hepatocellular carcinoma after curative resection

Annals of Surgical Oncology
Dongtai ChenWeian Zeng

Abstract

The beta2-adrenergic receptor (Beta2-AR) is overexpressed and highly associated with poor prognosis in many malignancies. Nevertheless, the role of Beta2-AR in hepatocellular carcinoma (HCC) has not been thoroughly elucidated. The aim of this study is to investigate the expression of Beta2-AR and its clinicopathological/prognostic value in HCC patients after curative resection. Semiquantitative reverse transcription PCR (RT-PCR) and real-time quantitative PCR (qPCR) were used to measure Beta2-AR RNA expression in 60 pairs of HCC tumors and matched nontumorous tissues. Beta2-AR expression was detected in HCC cell lines by Western blot analysis. Furthermore, we investigated Beta2-AR expression in correlation with the clinicopathological features and analyzed the potential prognostic significance of Beta2-AR in 192 HCC patients by immunohistochemistry (IHC). Upregulation of Beta2-AR mRNA was significantly higher in HCC tumor tissues than in their paired nontumorous liver specimens. The expression of Beta2-AR protein was detected in five HCC cell lines. Positive Beta2-AR protein expression was significantly associated with a high α-fetoprotein (AFP) level (P = 0.001), large tumor size (P < 0.001), tumor encapsulation (P = 0.002), v...Continue Reading

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Citations

Aug 15, 2013·Annals of Surgical Oncology·Boqing WangTiebang Kang
Nov 26, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Akira ShimizuOsamu Ishikawa
Nov 30, 2014·Medical Oncology·Chenwei PanZhenzhen Pan
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May 25, 2021·American Journal of Physiology. Endocrinology and Metabolism·Yun ShiAmrita Kamat

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