The Bewildering Effect of AMPK Activators in Alzheimer's Disease: Review of the Current Evidence

BioMed Research International
Brhane Teklebrhan AssefaMeles Tekie Gidey

Abstract

Alzheimer's disease is a multifactorial neurodegenerative disease characterized by progressive cognitive dysfunction. It is the most common form of dementia. The pathologic hallmarks of the disease include extracellular amyloid plaque, intracellular neurofibrillary tangles, and oxidative stress, to mention some of them. Despite remarkable progress in the understanding of the pathogenesis of the disease, drugs for cure or disease-modifying therapy remain somewhere in the distance. From recent time, the signaling molecule AMPK is gaining enormous attention in the AD drug research. AMPK is a master regulator of cellular energy metabolism, and recent pieces of evidence show that perturbation of its function is highly ascribed in the pathology of AD. Several drugs are known to activate AMPK, but their effect in AD remains to be controversial. In this review, the current shreds of evidence on the effect of AMPK activators in Aβ accumulation, tau aggregation, and oxidative stress are addressed. Positive and negative effects are reported with regard to Aβ and tauopathy but only positive in oxidative stress. We also tried to dissect the molecular interplays where the bewildering effects arise from.

References

Dec 30, 1998·Journal of Neural Transmission·G E GibsonJ P Blass
Feb 15, 2001·Dementia and Geriatric Cognitive Disorders·D A PowerD O'Neill
Jun 8, 2001·Annual Review of Biochemistry·S Y RothC D Allis
Aug 7, 2001·Journal of Neuropathology and Experimental Neurology·A NunomuraM A Smith
Sep 25, 2002·Neurobiology of Disease·Elena TamagnoMassimo Tabaton
Dec 10, 2002·Neurobiology of Aging·Min XuYue-Ming Li
Aug 7, 2004·Circulation Research·Jean-Luc Wautier, Ann Marie Schmidt
Dec 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Darius C FewlassNikolaos Tezapsidis
Dec 8, 2004·The Journal of Cell Biology·Christoph Kaether, Christian Haass
Dec 14, 2004·The Journal of Biological Chemistry·Fusheng YangGregory M Cole
Dec 23, 2004·Journal of Neural Transmission·Y TongW Song
Feb 15, 2005·Neurobiology of Aging·Mark A SmithGeorge Perry
Feb 22, 2005·Free Radical Biology & Medicine·Quan LiuGeorge Perry
Apr 16, 2005·The Journal of Biological Chemistry·Della C DavidJürgen Götz
Jun 15, 2005·Molecular Neurobiology·Xiongwei ZhuMark A Smith
Jan 25, 2006·Chemico-biological Interactions·M ValkoM Mazur
Feb 9, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chad A DickeyLeonard Petrucelli
Sep 1, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Latha DeviHindupur K Anandatheerthavarada
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Nov 16, 2006·Current Pharmaceutical Design·Chewki Ziani-CherifFatima Z Brixi-Gormat
Jan 6, 2007·Journal of Neuropathology and Experimental Neurology·Chenere P RamseyKelly L Jordan-Sciutto
Mar 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emmanuel PlanelKaren E Duff
Jun 21, 2007·PloS One·Simon MelovAshley I Bush
Jul 6, 2007·Nature Clinical Practice. Neurology·Haipeng ChengGopal Thinakaran
Oct 6, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Giulio CeolottoAngelo Avogaro
Dec 14, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emmanuel PlanelAkihiko Takashima
Mar 25, 2008·Neurobiology of Aging·Karen F HoldenUNKNOWN Health ABC study
Aug 19, 2008·Molecular and Cellular Neurosciences·Katja KanninenJari Koistinaho
Sep 20, 2008·Biochemical and Biophysical Research Communications·Steven J GrecoNikolaos Tezapsidis
Dec 17, 2008·Annals of the New York Academy of Sciences·Jeffrey A JohnsonPei-Chun Chen
Dec 24, 2008·Journal of Neuropathology and Experimental Neurology·Carl JulienFrédéric Calon
Feb 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yaomin ChenFrancesca-Fang Liao
May 12, 2009·Neuroscience Letters·Steven J GrecoNikolaos Tezapsidis

❮ Previous
Next ❯

Citations

Aug 23, 2020·Molecular Neurobiology·Archna SharmaPing Wang
Feb 5, 2021·Mechanisms of Ageing and Development·Jacopo SabbatinelliFabiola Olivieri
Mar 30, 2021·Ageing Research Reviews·Rohan GuptaPravir Kumar
Jun 1, 2021·Frontiers in Pharmacology·Mercedes Garcia-GilMaria Grazia Tozzi
Aug 17, 2021·Frontiers in Cellular Neuroscience·Yu-Ju Liu, Yijuang Chern
Oct 12, 2021·Expert Opinion on Drug Metabolism & Toxicology·Natalie R NeumannVasilis Vasiliou

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
ubiquitination
acetylation

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Related Papers

Current Protein & Peptide Science
Luping YangRongjiang Jin
Nihon rinsho. Japanese journal of clinical medicine
Yusuke HadaToshimasa Yamauchi
Current Biology : CB
D Carling
© 2021 Meta ULC. All rights reserved