The Bidirectional Relationship Between Cancer Epigenetics and Metabolism.

Annual Review of Cancer Biology
Luke T IzzoKathryn E Wellen

Abstract

Metabolic and epigenetic reprogramming are characteristics of cancer cells that, in many cases, are linked. Oncogenic signaling, diet, and tumor microenvironment each influence the availability of metabolites that are substrates or inhibitors of epigenetic enzymes. Reciprocally, altered expression or activity of chromatin-modifying enzymes can exert direct and indirect effects on cellular metabolism. In this article, we discuss the bidirectional relationship between epigenetics and metabolism in cancer. First, we focus on epigenetic control of metabolism, highlighting evidence that alterations in histone modifications, chromatin remodeling, or the enhancer landscape can drive metabolic features that support growth and proliferation. We then discuss metabolic regulation of chromatin-modifying enzymes and roles in tumor growth and progression. Throughout, we highlight proposed therapeutic and dietary interventions that leverage metabolic-epigenetic cross talk and have the potential to improve cancer therapy.

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Aug 28, 2021·International Journal of Molecular Sciences·Laura Leo, Nunzia Colonna Romano
Nov 26, 2021·Immunological Reviews·Heng-Yi ChenChan-Wang Jerry Lio

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