The bile acid-sensitive ion channel (BASIC), the ignored cousin of ASICs and ENaC

Channels
Dominik WiemuthStefan Gründer

Abstract

The DEG/ENaC gene family of ion channels is characterized by a high degree of structural similarity and an equally high degree of diversity concerning the physiological function. In humans and rodents, the DEG/ENaC family comprises 2 main subgroups: the subunits of the epithelial Na(+) channel (ENaC) and the subunits of the acid sensing ion channels (ASICs). The bile acid-sensitive channel (BASIC), previously known as BLINaC or INaC, represents a third subgroup within the DEG/ENaC family. Although BASIC was identified more than a decade ago, very little is known about its physiological function. Recent progress in the characterization of this neglected member of the DEG/ENaC family, which is summarized in this focused review, includes the discovery of surprising species differences, its pharmacological characterization, and the identification of bile acids as putative natural activators.

References

Nov 17, 1995·The Journal of Biological Chemistry·R WaldmannM Lazdunski
Apr 5, 1996·The Journal of Biological Chemistry·M P PriceM J Welsh
May 1, 1996·Seminars in Liver Disease·R A Marinelli, N F Larusso
Mar 13, 1997·Nature·R WaldmannM Lazdunski
Aug 22, 1997·The Journal of Biological Chemistry·R WaldmannM Lazdunski
Dec 31, 1997·The Journal of Biological Chemistry·E LinguegliaM Lazdunski
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·C C ChenJ N Wood
Aug 24, 1999·The Journal of Physiology·H SakaiM Lazdunski
Jun 14, 2000·Neuroreport·S GründerJ P Ruppersberg
Jan 5, 2002·Physiological Reviews·Karl Kunzelmann, Marcus Mall
Jun 28, 2002·Physiological Reviews·Stephan Kellenberger, Laurent Schild
Jan 16, 2003·Neuron·David C Immke, Edwin W McCleskey
Apr 5, 2003·American Journal of Physiology. Cell Physiology·Ai-Yu GongNicholas F LaRusso
Mar 10, 2004·The Journal of Biological Chemistry·Rebecca P HugheyThomas R Kleyman
May 19, 2004·The Journal of General Physiology·Mouhamed S AwaydaWarren G Hill
Jun 17, 2005·Nature Reviews. Neuroscience·Delia Belelli, Jeremy J Lambert
Feb 14, 2006·Pharmacology & Therapeutics·Susan I V Judge, Christopher T Bever
Jun 3, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·Ulrich Beuers
Jan 6, 2007·The Journal of Physiology·Xuanmao Chen, Stefan Gründer
Apr 7, 2007·Current Opinion in Gastroenterology·Pamela Tietz Bogert, Nicholas F LaRusso
Sep 21, 2007·Nature·Jayasankar JastiEric Gouaux
Oct 4, 2007·The Journal of Biological Chemistry·Andjelko GolubovicStefan Gründer
Nov 17, 2009·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Bettina KruegerAlexei Diakov
Feb 2, 2010·Neuropharmacology·Xuanmao ChenJohn F MacDonald
Feb 18, 2010·The Journal of Biological Chemistry·Stefan DürrnagelStefan Gründer
Jul 27, 2010·The Journal of Biological Chemistry·Dominik Wiemuth, Stefan Gründer
Sep 3, 2010·Pharmacology & Therapeutics·Emmanuel DevalEric Lingueglia
Jun 28, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dominik WiemuthStefan Gründer
Jul 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Anne DelaunayEmmanuel Deval
Feb 14, 2013·The Journal of Biological Chemistry·Nina BoikoJames D Stockand
Jun 21, 2013·Nature Reviews. Neuroscience·John A WemmieCollin J Kreple
Jul 12, 2013·Pflügers Archiv : European journal of physiology·Cathérine M T LefèvreDominik Wiemuth
Nov 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Steven M PaulCharles F Zorumski

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Citations

Jan 15, 2015·Neuropharmacology·Stefan Gründer, Michael Pusch
Jun 10, 2016·British Journal of Pharmacology·Emilie BoscardinStephan Kellenberger
May 17, 2019·The Journal of Biological Chemistry·Xue-Ping WangOssama B Kashlan
Apr 20, 2020·The Journal of Physiology·Matthew L RookDavid M MacLean
Sep 30, 2016·The Journal of Biological Chemistry·Axel SchmidtDominik Wiemuth
Jul 5, 2017·Pflügers Archiv : European journal of physiology·Akihiko FujimotoYasuo Furukawa
Jun 19, 2019·Biomolecules·Yoshimitsu Kiriyama, Hiromi Nochi
Aug 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Timothy LynaghStephan A Pless
May 18, 2019·Purinergic Signalling·Axel SchmidtDominik Wiemuth
Sep 9, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Babina Sanjel, Won-Sik Shim
Feb 20, 2015·The Journal of Experimental Biology·Stefan Gründer, Marc Assmann
Sep 23, 2021·Pflügers Archiv : European journal of physiology·Shari WiegreffeDominik Wiemuth

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