The biliprotein C-phycocyanin modulates the early radiation response: a pilot study

Mutation Research
Katia G IvanovaRayna N Boteva

Abstract

This study analyzed the effects of biliprotein C-phycocyanin (C-PC) on the enzymatic antioxidant defence system in lymphocytes of nuclear power-plant workers and non-exposed controls. Changes in the protein levels of manganese super oxide dismutase (MnSOD), catalase and glutathione-S-transferase (GST) were used as markers for early biological effects of a single in vitro exposure of cells to: (i) 2Gy gamma rays; (ii) 5muM C-PC; and (iii) a combination of C-PC plus irradiation with 2Gy. The results showed that C-PC selectively stimulated the lymphocyte antioxidant defence system of occupationally exposed subjects. The activation of the antioxidant protective mechanisms as part of the early radiation response was probably related to the chronic low-dose occupational exposure. The modulating capacity of C-PC at the molecular level may be of interest for the protection of occupationally exposed persons.

References

Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·R HardmeierG Lubec
Feb 7, 2001·International Journal of Radiation Biology·A BravardO Rigaud
Jan 5, 2002·Physiological Reviews·Wulf Dröge
May 29, 2003·Current Protein & Peptide Science·Ch RomayV Rimbau
Jun 27, 2003·Free Radical Biology & Medicine·Anne TulardAnne Bravard
Sep 2, 2003·The Journal of Pathology·Laurens KruidenierHein W Verspaget
Sep 29, 2005·Radiation Research·Patricia CramersJos C S Kleinjans
Nov 8, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bing LiXianming Chu
May 2, 2006·Journal of Photochemistry and Photobiology. B, Biology·Baosheng GeYuhong Ren
Feb 13, 2008·Journal of Cellular and Molecular Medicine·H K MadhyasthaM Maruyama

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Citations

Dec 5, 2015·International Journal of Radiation Biology·Olya KatsarskaRayna Boteva
Mar 15, 2013·International Journal of Radiation Biology·Katia StankovaRayna Boteva
Jun 15, 2011·Brain Research Bulletin·Giselle Pentón-RolEduardo Pentón-Arias
Dec 18, 2015·Dose-response : a Publication of International Hormesis Society·Katia StankovaRayna Boteva
Sep 5, 2020·Bioprocess and Biosystems Engineering·Sivaprakasam SivasankariElsayed Fathi Abd Allah
Nov 23, 2018·Biochimica Et Biophysica Acta. Bioenergetics·Konstantin E KlementievAndrew B Rubin
Nov 26, 2020·Food Research International·Tomas LafargaFrancisco Gabriel Acién-Fernández

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