The binding of Aβ1-42 to lipid rafts of RBC is enhanced by dietary docosahexaenoic acid in rats: Implicates to Alzheimer's disease

Biochimica Et Biophysica Acta
Michio HashimotoO Shido

Abstract

Once amyloid β peptides (Aβs) of the Alzheimer's disease build up in blood circulation, they are capable of binding to red blood cell (RBC) and inducing hemolysis of RBC. The mechanisms of the interactions between RBC and Aβ are largely unknown; however, it is very important for the therapeutic target of Aβ-induced hemolysis. In the present study, we investigated whether Aβ1-42 interacts with caveolin-1-containing detergent-resistant membranes (DRMs) of RBC and whether the interaction could be modulated by dietary pre-administration of docosahexaenoic acid (DHA). DHA pre-administration to rats inhibited hemolysis by Aβ1-42. This activity was accompanied by increased DHA levels and membrane fluidity and decreased cholesterol level, lipid peroxidation, and reactive oxygen species in the RBCs of the DHA-pretreated rats, suggesting that the antioxidative property of DHA may rescue RBCs from oxidative damage by Aβ1-42. The level of caveolin-1 was augmented in the DRMs of DHA-pretreated rats. Binding between Aβ1-42 and DRMs of RBC significantly increased in DHA-rats. When fluorescently labeled Aβ1-42 (TAMRA-Aβ1-42) was directly infused into the bloodstream, it again occupied the caveolin-1-containing DRMs of the RBCs from the DHA-rat...Continue Reading

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Citations

Aug 25, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Shahdat HossainHussain Shahjalal
Jul 15, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Shahdat HossainHussain Shahjalal
Jul 19, 2016·Critical Reviews in Biotechnology·Michio HashimotoHiroyuki Arai
Feb 24, 2016·Nutrients·Michael J WeiserM Hasan Mohajeri
Jan 13, 2018·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Michio Hashimoto
May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michio HashimotoOsamu Shido
Nov 30, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Brenda Yasie LeeZoya Leonenko
May 15, 2019·International Journal of Molecular Sciences·Stephanie AndradeMaria do Carmo Pereira
Oct 18, 2019·Journal of Nutritional Science and Vitaminology·Marzan SarkarMichio Hashimoto
Nov 19, 2019·Frontiers in Physiology·Juan Pablo Zuniga-Hertz, Hemal H Patel
Jan 9, 2020·Nitric Oxide : Biology and Chemistry·Francesca LeoMiriam M Cortese-Krott

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