PMID: 6169369Jul 27, 1981Paper

The binding of androgen receptor to DNA and RNA

Biochimica Et Biophysica Acta
S Y Lin, S Ohno

Abstract

The androgen receptor from mouse kidney cytosol has been studied for its nucleic acid binding properties by DNA-cellulose centrifugation assay. The receptor appears to bind to RNA (mRNA, tRNA, rRNA) as well as to DNA. Salt and heat activation of the androgen receptor enhances both DNA and RNA binding. The receptor binds slightly better to denatured DNA than to native DNA. The androgen receptor binds about 2-fold tighter to poly(dG-dC) than to poly (dA-dT). The interaction of the receptor with DNA is not greatly affected by the BrdUrd substitution. The observation that androgen receptor shows a significant affinity to RNA may imply that androgen receptor-RNA interaction could play a role in gene regulation.

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Citations

Feb 1, 1986·Journal of Steroid Biochemistry·T Thomas, D T Kiang
May 1, 1989·Journal of Steroid Biochemistry·G P RossiniJ A Gustafsson
Jan 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P K EagonL E Porter
May 17, 1982·European Journal of Biochemistry·S Lin, S Ohno
Aug 2, 1983·Biochimica Et Biophysica Acta·S Y Lin, S Ohno
Feb 1, 1987·Molecular and Cellular Endocrinology·G P Rossini

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