The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

Life Sciences
Mitra Abbasifard, Hossein Khorramdelazad

Abstract

Interleukin-6 (IL-6), known as an inflammatory cytokine, can be involved in many innate and adaptive immune responses. The role of IL-6 in the pathogenesis of the novel coronavirus disease 2019 (COVID-19) has recently received much more attention due to the spread of the virus and its pandemic potential. Cytokine storm is among the most critical pathological events in patients affected with coronaviruses (CoVs), i.e., severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and COVID-19, causing inflammation-induced lung injury and also occurring as a result of dysregulation of immune responses to the mentioned viruses. IL-6, along with some other inflammatory cytokines, including IL-1 beta (β), IL-8, and tumor necrosis factor-alpha (TNF-α), as well as inflammatory chemokines, can significantly contribute to, fever, lymphopenia, coagulation, lung injury, and multi-organ failure (MOF). Therefore, researchers are to explore novel approaches to treat the disease through targeting of IL-6 and its receptors based on prior experience of other disorders. In this review article, the latest findings on the role of IL-6 in the pathogenesis of COVID-19, as well as therapeutic persp...Continue Reading

Citations

Feb 10, 2021·Critical Care : the Official Journal of the Critical Care Forum·Maria Clara Saad MenezesJosé Otavio Costa Auler
Mar 3, 2021·Cell Death Discovery·André C FerreiraThiago Moreno L Souza
Apr 21, 2021·Expert Review of Clinical Immunology·Nicola PotereAldo Bonaventura
May 28, 2021·Journal of Family Medicine and Primary Care·Manal O AlharthiAhmed M Kabel
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