The bioartificial pancreas (BAP): Biological, chemical and engineering challenges

Biochemical Pharmacology
Veronica IacovacciPaolo Dario

Abstract

The bioartificial pancreas (BAP) represents a viable solution for the treatment of type 1 diabetes (T1D). By encapsulating pancreatic cells in a semipermeable membrane to allow nutrient, insulin and glucose exchange, the side effects produced by islets and whole organ transplantation-related immunosuppressive therapy can be circumvented. Several factors, mainly related to materials properties, capsule morphology and biological environment, play a key role in optimizing BAP systems. The BAP is an extremely complex delivery system for insulin. Despite considerable efforts, in some instances meeting with limited degree of success, a BAP capable of restoring physiological pancreas functions without the need for immunosuppressive drugs and of controlling blood glucose levels especially in large animal models and a few clinical trials, does not exist. The state of the art in terms of materials, fabrication techniques and cell sources, as well as the current status of commercial devices and clinical trials, are described in this overview from an interdisciplinary viewpoint. In addition, challenges to the creation of effective BAP systems are highlighted including future perspectives in terms of component integration from both a biolog...Continue Reading

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Citations

Mar 17, 2018·The International Journal of Artificial Organs·Katarzyna SkrzypekDimitrios Stamatialis
Jun 26, 2018·Journal of Materials Science. Materials in Medicine·Katarzyna SkrzypekDimitrios Stamatialis
Jun 23, 2020·Macromolecular Bioscience·Katarzyna SkrzypekDimitrios Stamatialis
Sep 9, 2020·Nature Metabolism·Thierry Berney, Ekaterine Berishvili
Aug 25, 2017·Scientific Reports·Katarzyna SkrzypekDimitrios Stamatialis
Dec 3, 2020·APL Bioengineering·Arianna Menciassi, Veronica Iacovacci
Jul 16, 2021·Journal of Tissue Engineering·Edward X HanLaura E Niklason
Dec 11, 2020·ACS Biomaterials Science & Engineering·Alisa M WhiteXiaoming He

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