PMID: 2662Dec 1, 1975

The bioavailability in man of ICRF-159 a new oral antineoplastic agent

The Journal of Pharmacy and Pharmacology
P J CreavenD A Alford

Abstract

The bioavailability of the antineoplastic agent, ICRF-159, has been examined in 12 patients receiving the drug in single and subdivided dose schedules in an attempt to account for the differences in toxicity found with the different schedules clinically. Recovery of radioactivity in the urine after single large doses (13.3-19.4 g) was 8.5 +/- 3.0% of the administered dose. After doses of 3.8-5.55 g recovery was 22.7 +/- 10.5% and after the same dose subdivided into 3 equal aliquots it was 52 +/- 8.7%. Unrecovered radioactivity was largely accounted for in the faeces. Plasma radioactivity levels in 2 patients after high and low dose were equivalent. Toxicity of the drug paralleled urinary recovery of radioactivity. It is concluded that schedule dependence of toxicity of ICRF-159 is at least partly due to bioavailability factors.

References

Mar 29, 1969·British Medical Journal·K HellmannJ V Bond
Apr 26, 1969·Nature·A M CreightonS Whitecross

Citations

Jan 1, 1990·Cancer Chemotherapy and Pharmacology·T NaritaS Tsukagoshi
Aug 1, 1976·Journal of Pharmaceutical Sciences·F W Goodhart, M L Eichman
Nov 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R E BelletF M Muggia
Mar 1, 1980·The British Journal of Dermatology·D J AthertonY F Williams
Nov 1, 1981·Clinical and Experimental Dermatology·D J Atherton
Sep 15, 1983·International Journal of Cancer. Journal International Du Cancer·S A MetcalfeB T Hill

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Drug Administration Schedule
Feces
Malignant Neoplasms
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