The Bioavailability of Various Oral Forms of Folate Supplementation in Healthy Populations and Animal Models: A Systematic Review

The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy
Jessica BayesJanet Schloss

Abstract

Folate is an essential nutrient required for many different functions in the body. It is particularly important for DNA synthesis, immune functions, and during pregnancy. Folate supplements are commonly prescribed by health professionals for a number of different conditions, however, the absorption of the different derivatives remains unclear. The aim of this review was to assess the bioavailability of various forms of folate supplements in healthy populations and animal models. A systematic literature review was conducted of original research, which assessed the bioavailability of different oral forms of folate in healthy adults or animal models. The following databases were searched: PubMed (U.S. National Library of Medicine), ProQuest Medical Collection (ProQuest) and ScienceDirect (Elsevier) up to March 30, 2017. The inclusion criteria consisted of both animal and human research, no disease state or condition, and assessed levels after an intervention of a folate derivative. A total of 23 studies out of 5226 met the full inclusion criteria. Of these, 4 were animal studies and 19 were human studies. There was variation in supplement forms used with the most commonly tested being folic acid followed by 5-methylenetetrahydrofo...Continue Reading

References

Jun 1, 1992·The American Journal of Clinical Nutrition·J F GregoryJ J Cerda
Mar 1, 1991·The American Journal of Clinical Nutrition·J F GregoryJ J Cerda
Jan 14, 1998·European Journal of Clinical Nutrition·A S Truswell, S Kounnavong
Apr 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Simonetta FrisoJacob Selhub
Aug 12, 2003·The British Journal of Nutrition·Peter SandersonUNKNOWN UK Food Standards Agency
Feb 27, 2004·The American Journal of Clinical Nutrition·Alida Melse-BoonstraPetra Verhoef
Feb 28, 2004·The Journal of Nutrition·Kristina PentievaJohn M Scott
Jun 11, 2004·Annual Review of Nutrition·Mark J Koury, Prem Ponka
Dec 14, 2006·JAMA : the Journal of the American Medical Association·Lydia A BazzanoJiang He
Jul 12, 2007·European Journal of Clinical Nutrition·P H C J VerlindeE H M Temme
Apr 24, 2009·European Journal of Nutrition·Darío Pérez-ConesaGaspar Ros
Jan 14, 2010·The Journal of Clinical Psychiatry·Maurizio Fava, David Mischoulon
Jun 3, 2011·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Jananie BalendranAlec Welsh
May 15, 2012·Journal of the Academy of Nutrition and Dietetics·Kevin C MakiMary R Dicklin

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Citations

Sep 6, 2020·Journal of Clinical Medicine·Maša Vidmar GoljaIrena Mlinarič-Raščan

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Software Mentioned

PRISMA
ProQuest Medical Collection
ProQuest

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