PMID: 163608Feb 1, 1975Paper

The biochemical, clinical, and genetic features of type III hyperlipoproteinemia

Annals of Internal Medicine
J MorganrothD S Fredrickson


The clinical and biochemical features of type III hyperlipoproteinemia are described in 49 patients from 23 to 70 years of age. An increase in very low-density lipoproteins (VLDL) of abnormal chemical composition was the basis for diagnosis. The untreated patients all had hypercholesterolemia and hyperglyceridemia, and, on the average, decreased concentrations of both low- and high-density lipoproteins. Seventy-four percent had xanthomas, and classic "xanthoma striata palmaris" was found in more than half. Twenty-seven percent had ischemic heart disease, detected earlier in men than in women. Twenty-seven percent had peripheral vascular disease (compared to 4% of subjects with type II hyperlipoproteinemia). Twenty-five of 35 subjects achieved normal lipid levels with dietary therapy alone. Analysis of 29 kindred showed hyperlipidemia in half of adult blood relatives; half of these had type III, the remainder usually had sample endogenous hyperglyceridemia (type IV). Only 2 of 55 children less than 20 years of age were affected, both with type IV.


Jan 1, 1997·Genetic Epidemiology·G FeussnerC Fischer
Sep 1, 1991·Diabetes/metabolism Reviews·Y D Chen, G M Reaven
Jan 1, 1980·Archives of Dermatological Research·B J Vermeer, F C Reman
Jan 1, 1986·Clinical Rheumatology·B FishelA Rubinstein
Mar 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·F C BallantyneC J Packard
Aug 14, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·R KnöflerA Takada
Mar 29, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·T TeramotoM Yamanaka
Nov 1, 1981·Atherosclerosis·P M StuytA Van't Laar
Aug 1, 1994·Atherosclerosis·E J SchaeferP W Wilson
Apr 15, 1995·Thrombosis Research·R KnöflerA Takada
Jan 1, 1988·Pharmacology & Therapeutics·C R Sirtori, G Franceschini
Sep 1, 1993·Trends in Cardiovascular Medicine·S Fazio
Nov 13, 2001·The American Journal of Cardiology·E J SchaeferJ J Rubenstein
May 16, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·M OkazakiK Nakajima
Jan 15, 1999·Atherosclerosis·M S WeintraubI Grosskopf
Mar 25, 2000·Deutsche medizinische Wochenschrift·K Widhalm
May 24, 1986·Lancet·P H WinocourD C Anderson
Nov 27, 2008·European Journal of Human Genetics : EJHG·Peter HennemanAugustinus H M Smelt
Nov 27, 2008·European Journal of Human Genetics : EJHG·Juergen R Schaefer
Jan 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M L BlueC B Blum
Jan 1, 1991·Journal of Internal Medicine·P B Duell, E L Bierman
Oct 26, 2005·Journal of Gastroenterology and Hepatology·Jung-Cheng HsuYuan-Teh Lee
Dec 10, 2002·The Journal of the Association of Nurses in AIDS Care : JANAC·Thomas J BirkSheldon D Levine
Sep 11, 2012·The Journal of Clinical Endocrinology and Metabolism·Lars BerglundUNKNOWN Endocrine society
Feb 18, 2011·Journal of Atherosclerosis and Thrombosis·Asuka MitaniTaku Yamamura
Sep 6, 2003·Lancet·Paul Durrington
Aug 1, 2014·Current Atherosclerosis Reports·Paul N HopkinsM Nazeem Nanjee
Nov 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S OikawaT Toyota
Nov 19, 2013·The American Journal of Cardiology·Maen D Abou ZikiRonald G Crystal

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.