PMID: 7305280Jul 1, 1981

The biochemical genetics of human gamma-aminobutyric acid transaminase

Annals of Human Genetics
S Jeremiah, S Povey


1. Two methods have been devised for the detection after electrophoresis of gamma-aminobutyric acid transaminase (GABAT) isozymes. 2. GABAT isozymes can be detected in liver, brain, kidney, pancreas, heart, testis. spinal cord and upper jejunum. The greatest activity occurs in liver. 3. Three different commonly occurring electrophoretic types of GABAT have been identified. It seems likely that they are determined by two alleles at an autosomal locus (GABAT). 4. The gene frequencies of GABAT1 and GABAT2 in a random sample of European livers were 0.56 and 0.44 respectively. 5. The three banded patterns seen in heterozygotes suggest that GABAT is a dimeric enzyme. 6. GABA, beta-alanine and 5-aminovaleric acid can act as substrates for GABAT. 7. GABAT activity can be demonstrated in all areas of human brain with the exception of the corpus callosum. Brain samples from patients with Huntington's chorea show no abnormal GABAT activity or unusual phenotypes.


Feb 10, 2000·Archives of Biochemistry and Biophysics·Y K KooRichard B Silverman
Apr 1, 1995·Clinical Biochemistry·F Sherif, S S Ahmed
Dec 1, 1994·Progress in Neuro-psychopharmacology & Biological Psychiatry·F Sherif
Feb 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·F SherifL Oreland
Jan 1, 1992·Journal of Neural Transmission. General Section·F SherifL Oreland
Aug 26, 2014·Medicinal Research Reviews·Hyunbeom LeeRichard B Silverman
May 29, 2020·Journal of Biomolecular Structure & Dynamics·Anas Al-ObaidiKemal Yelekçi
Jan 1, 1989·British Journal of Clinical Pharmacology·J B BoltonA Richens

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ABAT gene

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