PMID: 8944225Jan 1, 1996Paper

The biochemical role of platelet-activating factor in reproduction

Progress in Lipid Research
R A FrenkelJ M Johnston

Abstract

The presence of Co-A independent transacylase activity in amnion cells and the preferential transfer of arachidonic acid to acceptor-ethanolamine plasmalogen provide a satisfactory explanation to the questions raised by the observation that arachidonate-enriched ethanolamine plasmalogen increases in amnion late in gestation without alteration in the total amount of ethanolamine glycerophospholipids. The proposed mechanism also serves as a link between the observed changes in glycerophospholipid composition and the generation of PAF. We have emphasized a role for PAF in fetal lung maturation, the initiation and maintenance of parturition, and in certain complications associated with a premature delivery. Although PAF is known to be the most potent lipid mediator yet described and its importance in reproductive biology is well documented, it is our view that these events cannot be attributed solely to PAF and in all likelihood a number of autacoids participate in these processes.

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Citations

Jul 21, 1998·Molecular Reproduction and Development·S Soubeyrand, P Manjunath
Jan 22, 2005·Pediatric Research·Jennifer H SteelMark H F Sullivan
May 18, 1999·The American Journal of Pathology·B D Flickinger, M S Olson
Jun 23, 2015·The Journal of Clinical Investigation·Lu GaoCarole R Mendelson
Sep 16, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Carole R MendelsonLu Gao
Jan 24, 2002·Biology of Reproduction·Céline CheminadeAlain B Legrand
Oct 12, 1999·The American Journal of Physiology·S G Greenberg, K E Clark
Nov 12, 2019·Frontiers in Endocrinology·Carole R MendelsonAlina P Montalbano
Oct 19, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jingfei ChenCarole R Mendelson
Nov 18, 2000·Biochimica Et Biophysica Acta·L W Tjoelker, D M Stafforini

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