Mutagenesis has remained an intriguing aspect of genetics since the beginning of this century, and its analysis has proceeded hand in hand with the elucidation of gene replication and expression. Interest in this area has further heightened with the growing awareness that numerous environmental agents may cause mutations in humans. These mutations may lead to metabolic as well as neoplastic diseases. Advances during the past 15 years have revealed two major classes of mutagenic mechanisms: directly induced base mispairing, and misrepair. Alkylating agents for instance, generate many different reaction products in DNA, but only two of these (O6-alkylguanine and O4-alkylthymine) are likely candidates for directly induced mispairing. He has also turned out to be an important mutagen, one that presents a particular serious challenge to large genomes; it converts cytosine to uracil and guanine to an analogue of cytosine. DNA lesions that interrupt DNA chain elongation, including many of other products of alkylation, often trigger an error-prone postreplication repair process. Current evidence suggests that this process involves in incorrect insertion of bases into gaps in progeny-strand DNA opposite such a lesion. Mutagenic mechanis...Continue Reading
Defective excision repair in a mutant of Micrococcus radiodurans hypermutable by some monofunctional alkylating agents
The role of misrepair processes in the isolation of new types of streptomycin-resistant mutants in Escherichia coli
Misrepair mutagenesis in Myxococcus xanthus: induction of rifampicin-resistant mutants by N-methyl-N'-nitro-N-nitrosoguanidine and ultraviolet-irradiation
The nucleotide-permeable Escherichia coli cell, a sensitive DNA repair indicator for carcinogens, mutagens, and antitumor agents binding covalently to DNA
Retardation of cell cycle progression in yeast cells recovering from DNA damage: a study at the single cell level
Apurinic endonuclease from Drosophila melanogaster: reduced enzymatic activity in excision-deficient mutants of the mei-9 and mus(2)201 Loci
2-Aminopurine and 5-bromouracil induce alleviation of type I restriction in Escherichia coli: mismatches function as inducing signals?
On the DNA polymerase-a mutant: immunofluorescence assay of UV-induced thymidine dimers in Aphr-4-2 cells
Necessity of quantum coherence to account for the spectrum of time-dependent mutations exhibited by bacteriophage T4
MMS mutagenesis in strains of Escherichia coli carrying the R46 mutagenic enhancing plasmid: phenotypic analysis of Arg+ revertants
MMS induction of different types of genetic damage in Aspergillus nidulans: a comparative analysis in mutagenesis
Mitochondrial mutagenesis in Saccharomyces cerevisiae. II. Methyl methanesulphonate and diepoxybutane
Genetic markers for quantitative mutagenesis studies in Chinese hamster ovary cells: characteristics of some recently developed selective systems
Effects of the umuC36 mutation on ultraviolet-radiation-induced base-change and frameshift mutations in Escherichia coli
Mutagenic interactions between near-ultraviolet (365 nm) radiation and alkylating agents in Escherichia coli
Azido analogs of acridine: photoaffinity probes for frameshift mutagenesis in Salmonella typhimurium
Quantitative forward-mutation specificity of mono-functional alkylating agents, ICR-191, and aflatoxin B1 in mouse lymphoma cells
Induced reversion of a Chinese hamster ovary triple auxotroph. Validation of the system with several mutagens
N-methyl-N'-nitro-N-nitrosoguanidine induced DNA sequence alteration; non-random components in alkylation mutagenesis
Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: a perspective
Quantitative mutagenesis at the adenosine kinase locus in Chinese hamster ovary cells. Development and characteristics of the selection system
A new strain of Salmonella typhimurium reverted by mitomycin C and N-methyl-N'-nitro-N-nitrosoguanidine--a possible universal tester for mutagenic compounds
The genetic activity of N6-hydroxyadenine and 2-amino-N6-hydroxyadenine in Escherichia coli, Salmonella typhimurium and Saccharomyces cerevisiae
Powerful mutagenicity of a bipyridylium herbicide in a nitrogen-fixing blue-green alga Nostoc muscorum
Comparison of the Escherichia coli umu+-encoded function with plasmid R46-mediated error-prone repair in DNA-damaged cells
Induction of temperature-sensitive 6-thioguanine-resistant mutants as a measure of base-pair substitution mutations in Chinese hamster ovary cells
HLA-A2 as a target for cell-mediated lympholysis: evidence from immunoselected HLA-A2 negative mutant cell lines
Mutagen-nucleic acid intercalative binding: structure of a 9-aminoacridine: 5-iodocytidylyl(3'-5')guanosine crystalline complex
Genetic control of enhanced mutability of mitochondrial DNA and gamma-ray sensitivity in Saccharomyces cerevisiae
Site exclusion and sequence specificity in binding of 9-aminoacridine to the deoxytetranucleotide dpApGpCpT
X-ray-structure of a cytidylyl-3',5'-adenosine-proflavine complex: a self-paired parallel-chain double helical dimer with an intercalated acridine dye
A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions
Different levels of induction of RecA protein in E. coli (PQ 10) after treatment with two related carcinogens
A novel guanine-guanine base pairing: crystal structure of a complex between 7-methylguanosine and its iodide
Excision of uracil residues in DNA: mechanism of action of Escherichia coli and Micrococcus luteus uracil-DNA glycosylases
Characterization of imperfect DNA duplexes containing unpaired bases and non-Watson-Crick base pairs
Structural studies of O6-methyldeoxyguanosine and related compounds: a promutagenic DNA lesion by methylating carcinogens
Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions
Properties of Streptomyces fradiae mutants blocked in biosynthesis of the macrolide antibiotic tylosin
Polynucleotide phosphorylase plays an important role in the generation of spontaneous mutations in Escherichia coli
Chemical carcinogens: a review of the science and its associated principles. U.S. Interagency Staff Group on Carcinogens
Induced mutagenesis in dam- mutants of Escherichia coli: a role for 6-methyladenine residues in mutation avoidance
Spontaneous and induced mutations to rifampicin, streptomycin and spectinomycin resistances in actinomycetes: mutagenic mechanisms and applications for strain improvement
Alteration of the DNA double helix conformation upon incorporation of mispairs as revealed by energy computations and pathways of point mutations
In vitro bypass of UV-induced lesions by Escherichia coli DNA polymerase I: specificity of nucleotide incorporation
Short-term tests for mutagenesis and carcinogenesis in drug toxicology: how to test and when to test is the question
In vitro inhibition of carcinogen-induced mutagenicity by Cassia occidentalis and Emblica officinalis
Rational and combinatorial approaches to engineering styrene production by Saccharomyces cerevisiae.
Evidence for transcriptase quantum processing implies entanglement and decoherence of superposition proton states
Protection of cultured Cyprinus carpio against a lethal viral disease by an attenuated virus vaccine
Mutation hotspots in the p53 gene in tumors of different origin: correlation with evolutionary conservation and signs of positive selection
Comparative mutagenicity of alkylsulfate and alkanesulfonate derivatives in Chinese hamster ovary cells
Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells
Frameshift and intragenic suppressor mutations in a Rous sarcoma provirus suggest src encodes two proteins
Revertants of a trans-dominant S49 mouse lymphoma mutant that affects expression of cAMP-dependent protein kinase
DNA repair in Syrian hamster embryo cells treated with 7,12-dimethylbenz[a]anthracene and its weakly carcinogenic 5-fluoro analog
Clinical genotyping: the need for interrogation of single nucleotide polymorphisms and mutations in the clinical laboratory
An ACCUMULATION AND REPLICATION OF CHLOROPLASTS 5 gene mutation confers light green peel in cucumber
The TRIM-NHL protein LIN-41 controls the onset of developmental plasticity in Caenorhabditis elegans
An exon skipping in a SEPALLATA-Like gene is associated with perturbed floral and fruits development in cucumber
Micrococcus luteus endonucleases for apurinic/apyrimidinic sites in deoxyribonucleic acid. 1. Purification and general properties
Coding properties of poly(deoxycytidylic acid) templates containing uracil or apyrimidinic sites: in vitro modulation of mutagenesis by deoxyribonucleic acid repair enzymes
Self base pairing in a complementary deoxydinucleoside monophosphate duplex: crystal and molecular structure of deoxycytidylyl-(3'-5')-deoxyguanosine
Base-pairing properties of N4-methoxydeoxycytidine 5'-triphosphate during DNA synthesis on natural templates, catalyzed by DNA polymerase I of Escherichia coli
Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels
A role for DNA polymerase in the specificity of nucleotide incorporation opposite N-acetyl-2-aminofluorene adducts
Binding of 9-aminoacridine to deoxydinucleoside phosphates of defined sequence: preferences and stereochemistry
A microplate version of the DNA-synthesis inhibition test for rapid detection of DNA-alteration potentials
Prediction of pairing schemes in RNA molecules-loop contributions and energy of wobble and non-wobble pairs
Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacI gene of Escherichia coli
On molecular mechanisms of nucleic acid synthesis. Fidelity aspects: 2. Contribution of protein-nucleotide recognition
Crystallographic studies of drug-nucleic acid interactions: proflavine intercalation between the non-complementary base-pairs of cytidilyl-3',5'-adenosine
Synthetic biology, genome mining, and combinatorial biosynthesis of NRPS-derived antibiotics: a perspective
Whole Genome Sequencing and a New Bioinformatics Platform Allow for Rapid Gene Identification in D. melanogaster EMS Screens
The CSR-1 endogenous RNAi pathway ensures accurate transcriptional reprogramming during the oocyte-to-embryo transition in Caenorhabditis elegans
Recovery from inhibition by radiation of transcriptionally controlled enzyme induction: a possible probe for DNA repair
Reversion of a mutation affecting the molecular weight of HGPRT: intragenic suppression and localization of X-linked genes
Use of a Sibling Subtraction Method for Identifying Causal Mutations in Caenorhabditis elegans by Whole-Genome Sequencing
Genotoxicity of tobacco smoke-derived aromatic amines and bladder cancer: current state of knowledge and future research directions
Massive thermal acceleration of the emergence of primordial chemistry, the incidence of spontaneous mutation, and the evolution of enzymes.
Mutational specificities of environmental carcinogens in the lacl gene of Escherichia coli. III: The cyclic nitrosamine N-nitrosopyrrolidine is a complex mutagen
Delineating biological pathways unique to embryonic stem cell-derived insulin-producing cell lines from their noninsulin-producing progenitor cell lines
Two androecious mutations reveal the crucial role of ethylene receptors in the initiation of female flower development in Cucurbita pepo.
Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?
HGPRT- mutants of V79 cells that revert specifically by base pair substitution and frameshift mutations
Primary mutations in calmodulin prevent activation of the Ca(++)-dependent Na+ channel in Paramecium
Aneuploidy in Drosophila. III: Aneuploidogens inhibit in vitro assembly of taxol-purified Drosophila microtubules
CLAVATA1-type receptor-like kinase CsCLAVATA1 is a putative candidate gene for dwarf mutation in cucumber
Methylation of DNA in target and non-target organs of the rat with methylbenzylnitrosamine and dimethylnitrosamine
Induction and expression of mutations at multiple drug-resistance marker loci in Chinese hamster ovary cells
Rhodosporidium Banno: dose-effect relations, mutagenic efficiency, and spectrum of mutants in the induction of auxotrophic mutants by ultraviolet light and N-methyl-N'-nitro-N-nitrosoguanidine
Frameshift mutations produced by 9-aminoacridine in wild-type, uvrA and recA strains of Escherichia coli; specificity within a hotspot
Organ specificity of the bladder carcinogen 4-aminobiphenyl in inducing DNA damage and mutation in mice
Double-proton transfer in adenine-thymine and guanine-cytosine base pairs. A post-Hartree-Fock ab initio study
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