The biocompatibility of polyaniline and polypyrrole: A comparative study of their cytotoxicity, embryotoxicity and impurity profile

Materials Science & Engineering. C, Materials for Biological Applications
Petr HumpolíčekMarián Lehocký

Abstract

Conducting polymers (CP), namely polyaniline (PANI) and polypyrrole (PPy), are promising materials applicable for the use as biointerfaces as they intrinsically combine electronic and ionic conductivity. Although a number of works have employed PANI or PPy in the preparation of copolymers, composites, and blends with other polymers, there is no systematic study dealing with the comparison of their fundamental biological properties. The present study, therefore, compares the biocompatibility of PANI and PPy in terms of cytotoxicity (using NIH/3T3 fibroblasts and embryonic stem cells) and embryotoxicity (their impact on erythropoiesis and cardiomyogenesis within embryonic bodies). The novelty of the study lies not only in the fact that embryotoxicity is presented for the first time for both studied polymers, but also in the elimination of inter-laboratory variations within the testing, such variation making the comparison of previously published works difficult. The results clearly show that there is a bigger difference between the biocompatibility of the respective polymers in their salt and base forms than between PANI and PPy as such. PANI and PPy can, therefore, be similarly applied in biomedicine when solely their biological...Continue Reading

Citations

Nov 14, 2019·Polymers·Kateřina SkopalováPetr Humpolíček
Oct 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Brenda G MolinaCarlos Aleman
Sep 25, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Nela MarákováMarián Lehocký
Sep 25, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Hugo Gajardoni de LemosEveraldo Carlos Venancio
Jan 10, 2021·International Journal of Molecular Sciences·Kateřina SkopalováPetr Humpolíček
Feb 19, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ernest CheahDarren Svirskis
Apr 23, 2021·Acta Biomaterialia·Yimeng LiLu Wang
Jan 1, 2021·Talanta·Julien BiscayLynn Dennany
Jul 24, 2021·Essays in Biochemistry·Parvin AlizadehNureddin Ashammakhi
Jul 27, 2021·International Journal of Pharmaceutics·Niloufar Hosseini-GivMaryam M Matin
Aug 29, 2019·ACS Omega·Yuriy NoskovAlexander Pud
Sep 11, 2019·Journal of Medicinal Chemistry·Ehsan Nazarzadeh ZareGiuseppe Perale
Aug 28, 2021·International Journal of Molecular Sciences·Arsalan Ul HaqPaolo Di Nardo
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Elton Marlon de Araújo LimaCelso Pinto de Melo

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