PMID: 16519406Mar 8, 2006Paper

The biocompatibility research of functional Schwann cells induced from bone mesenchymal cells with chitosan conduit membrane

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
Peixun ZhangBaoguo Jiang

Abstract

To explore the adhesion and proliferation characteristics of bone marrow mesenchymal cells (MSCs) to chitosan conduit membrane, MSCs were induced by a sequential composition Beta-mercaptoethanol, retinoic acid, forskolin, basic-FGF, PDGF and heregulin. Schwann Cell markers, namely S-100 and GFAP, were used to discriminate the induced MSCs' properties by immunofluorescent staining. These results suggested that MSCs can take on Schwann cell's phenotype in vitro and the induce MSCs were gifted with good biocompatibility to biogradable chitosan conduit membrane. The results provided the possibilities to using the induced MSCs with chitosan conduit membrane in artificial peripherial nerve fields to promote nerve regeneration.

References

Feb 16, 2000·Progress in Retinal and Eye Research·M Dezawa, E Adachi-Usami
Jun 22, 2002·Nature·Yuehua JiangCatherine M Verfaillie
Oct 24, 2002·Neurological Research·Pedro CuevasDiana Reimers
Nov 25, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kuan-Der LeeOscar Kuang-Sheng Lee
Jan 18, 2005·Cell and Tissue Research·Darko BosnakovskiToru Fujinaga
Jun 25, 2005·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·Peixun ZhangBaoguo Jiang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.