The biodistribution, excretion and potential toxicity of different-sized Pd nanosheets in mice following oral and intraperitoneal administration

Biomaterials Science
Xiaolan ChenNanfeng Zheng

Abstract

Two-dimensional (2D) Pd-based nanomaterials with strong near-infrared absorption have recently shown great application prospects in cancer diagnosis and therapy. Most previous studies mainly focused on understanding the in vivo behaviors and treatment effects of these Pd-based nanomaterials after intravenous injection into mice. However, it remains unclear whether other administration routes will affect the in vivo biodistribution, excretion and potential toxicity of Pd-based nanomaterials. In this study, for the first time we systematically explored the in vivo behaviors of different-sized Pd nanosheets (NSs) (approximately 5 nm, 30 nm and 80 nm) following oral feeding and intraperitoneal injection. It was found that Pd NSs with oral administration had a rather low accumulation that decreased with time in all examined organs, and became almost undetectable in these organs at 24 h post-injection. In comparison, the intraperitoneally injected Pd NSs exhibited obvious time-dependent and size-dependent accumulations in the reticuloendothelial (RES) system including the liver and spleen within 24 h post-injection, and then the accumulation amounts decreased with the lapse of time. Moreover in tumor tissue, smaller-sized Pd NSs (5 n...Continue Reading

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Citations

Sep 28, 2018·Chemical Society Reviews·Yijing LiuXiaoyuan Chen
Nov 15, 2018·Chemical Communications : Chem Comm·Chongchong WangShaohua Wei
Nov 21, 2019·Drug Delivery·Yuzhu SunShuyu Xie
Apr 24, 2020·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Ali KermanizadehVicki Stone
Nov 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Duo SunNanfeng Zheng

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Methods Mentioned

BETA
dynamic light scattering

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