The biodistribution of [153Gd]Gd-labeled magnetic resonance contrast agents in a transgenic mouse model of renal failure differs greatly from control mice.

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Thaddeus J WadasCarolyn J Anderson

Abstract

Nephrogenic systemic fibrosis occurs in renally impaired patients who have undergone contrast enhanced MR examination using intravenous gadolinium-based contrast agents. The effect of impaired kidney function on the biodistribution of gadolinium-based contrast agents was investigated using radiolabeled (153/Nat) gadolinium-DOTA, (153/Nat) gadolinium-DTPA, and (153/Nat) gadolinium-DTPA-BMA in a transgenic mouse model of renal impairment. Renally impaired animals had more activity associated with their tissues than did control mice, and this increase varied according to the radiotracer injected. For example, after 7 days, renally impaired animals that received (153/Nat) Gd-DOTA had 3-fold (P < 0.037) more activity in their bone tissue, whereas renally impaired animals receiving (153/Nat) Gd-DTPA and (153/Nat) Gd-DTPA-BMA had 8-fold (P < 0.0001) and 24-fold (P < 0.0001) more activity in their bone tissue, respectively. These findings demonstrate that renal impairment dramatically alters the tissue distribution of Gd(3+) ions in vivo, which are likely a critical factor in the development of nephrogenic systemic fibrosis.

References

Jan 11, 2002·Journal of Medicinal Chemistry·Xiankai SunCarolyn J Anderson
Feb 13, 2002·The American Journal of Pathology·Kaya L AndrewsJeffrey H Miner
Mar 5, 2004·Journal of Medicinal Chemistry·C Andrew BoswellCarolyn J Anderson
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer E SpragueCarolyn J Anderson
Aug 4, 2006·Journal of the American Society of Nephrology : JASN·Peter MarckmannHenrik S Thomsen
May 18, 2007·Kidney International·T Grobner, F C Prischl
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Aneet DeoShawn E Cowper
Sep 15, 2007·Journal of the American Society of Nephrology : JASN·Sundararaman Swaminathan, Sudhir V Shah
Nov 30, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Willem J M MulderZahi A Fayad
Mar 18, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Marc PortClaire Corot
Apr 1, 2008·European Journal of Radiology·Jerrold L Abraham, Charu Thakral
Nov 13, 2008·Investigative Radiology·Thomas FrenzelHanns-Joachim Weinmann
Nov 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yi FengZheng-Rong Lu
Jan 17, 2009·Methods in Molecular Biology·Tim D HewitsonGavin J Becker
Jan 24, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ioannis ConstantinidisAthanassios Sambanis
Sep 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anne BeilvertZahi A Fayad
Nov 1, 2009·Metallomics : Integrated Biometal Science·Thomas H DarrahRobyn E Hannigan

❮ Previous
Next ❯

Citations

Dec 8, 2010·European Radiology·Henrik S Thomsen
Nov 13, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·F TárkányiA V Ignatyuk
Aug 7, 2012·European Radiology·Henrik S ThomsenUNKNOWN ESUR Contrast Medium Safety Committee
Sep 19, 2015·Regulatory Toxicology and Pharmacology : RTP·Hervé GiorgiPhilippe Bourrinet
Sep 27, 2014·Critical Reviews in Toxicology·Jean-Marc IdéeClaire Corot
Mar 5, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nathalie FretellierClaire Corot
Aug 8, 2014·American Journal of Physiology. Renal Physiology·Catherine DoBrent Wagner
May 26, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Viktor R DrelBrent Wagner
May 6, 2016·American Journal of Physiology. Renal Physiology·Brent WagnerYves Gorin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Y e A KarelinY e N Spiridonov
© 2021 Meta ULC. All rights reserved