The bioenergetics of integrin-based adhesion, from single molecule dynamics to stability of macromolecular complexes

Computational and Structural Biotechnology Journal
Laurent MacKay, Anmar Khadra

Abstract

The forces actively generated by motile cells must be transmitted to their environment in a spatiotemporally regulated manner, in order to produce directional cellular motion. This task is accomplished through integrin-based adhesions, large macromolecular complexes that link the actin-cytoskelton inside the cell to its external environment. Despite their relatively large size, adhesions exhibit rapid dynamics, switching between assembly and disassembly in response to chemical and mechanical cues exerted by cytoplasmic biochemical signals, and intracellular/extracellular forces, respectively. While in material science, force typically disrupts adhesive contact, in this biological system, force has a more nuanced effect, capable of causing assembly or disassembly. This initially puzzled experimentalists and theorists alike, but investigation into the mechanisms regulating adhesion dynamics have progressively elucidated the origin of these phenomena. This review provides an overview of recent studies focused on the theoretical understanding of adhesion assembly and disassembly as well as the experimental studies that motivated them. We first concentrate on the kinetics of integrin receptors, which exhibit a complex response to fo...Continue Reading

References

Dec 1, 1992·The Journal of Cell Biology·C M Regen, A F Horwitz
Jun 22, 1988·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M DemboD Hammer
Mar 1, 1995·The Journal of Cell Biology·R AlonT A Springer
Dec 1, 1996·Biophysical Journal·A Mogilner, G Oster
Apr 1, 1997·Biophysical Journal·E Evans, K Ritchie
Jan 31, 1998·The Journal of Biological Chemistry·A HuttenlocherA F Horwitz
Sep 9, 1999·The Journal of Cell Biology·I KaverinaJ V Small
Nov 5, 1999·Science·L B SmilenovG G Gundersen
Nov 26, 1999·FEBS Letters·M PfaffM H Ginsberg
Mar 14, 2000·Current Biology : CB·K I Anderson, R Cross
Jun 27, 2000·Biophysical Journal·C M LoY L Wang
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·E EvansS Simon
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·M ShimaokaT A Springer
Feb 21, 2002·Trends in Cell Biology·Angela GladingAlan Wells
Feb 23, 2002·Trends in Cell Biology·J Victor SmallKlemens Rottner
Aug 2, 2002·Cell·Benjamin Geiger, Alexander Bershadsky
Sep 18, 2002·Immunological Reviews·Carlo LaudannaEugene Butcher
Jan 28, 2003·Biophysical Journal·Feiya LiVincent T Moy
Apr 4, 2003·The Journal of Biological Chemistry·Peter Devreotes, Chris Janetopoulos
Oct 4, 2003·Science·Seiji TadokoroDavid A Calderwood
Oct 9, 2003·The Journal of Biological Chemistry·A Paul MouldMartin J Humphries
Nov 11, 2003·Nature Structural Biology·JianFeng ChenTimothy A Springer
Dec 6, 2003·Journal of Cell Science·Dusko IlićCaroline H Damsky
Jan 27, 2004·Nature Cell Biology·Donna J WebbAlan F Horwitz
Mar 26, 2004·Biophysical Journal·Pierre Sens, Matthew S Turner
Apr 20, 2004·Physical Review Letters·T Erdmann, U S Schwarz
Jun 23, 2004·PLoS Biology·Jun QinEdward F Plow
Jul 13, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A Nicolas, S A Safran
Jul 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Evan EvansCheng Zhu
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alice NicolasSamuel A Safran
Sep 7, 2004·Biophysical Journal·Xiaohui ZhangVincent T Moy
Sep 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·David R Kovar, Thomas D Pollard
Sep 24, 2004·Physiological Reviews·Michael C Brown, Christopher E Turner

❮ Previous
Next ❯

Citations

Nov 4, 2020·Chembiochem : a European Journal of Chemical Biology·Saidu SaniMonique Dontenwill
Nov 13, 2020·Journal of Theoretical Biology·Laurent MacKayAnmar Khadra
May 19, 2021·Cellular Signalling·Yasaswi Gayatri Mishra, Bramanandam Manavathi
Sep 21, 2021·Physical Biology·Elisabeth G Rens, Leah Edelstein-Keshet

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence-based microscopy
atomic force microscopy
GTPases

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Molecular Biology of the Cell
Guðlaug Katrín HákonardóttirGuy Tanentzapf
Cold Spring Harbor Perspectives in Biology
Anna Huttenlocher, Alan F Horwitz
Current Opinion in Cell Biology
Joshua A BroussardIrina Kaverina
© 2021 Meta ULC. All rights reserved